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Conception

When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.

TTC Active Letrozole Thread

497 replies

Angelselevenx · 28/02/2024 17:09

Struggling to find an active Letrozole thread. Recently been prescribed Letrozole as I have low progesterone and signs of ovulation not being as effective as it could be, albeit I still ovulate on my own.

Would love to hear success stories or chat to people who are going through TTC with letrozole now x

OP posts:
Thread gallery
17
Letrozolelastchance · 04/05/2024 20:14

Optimistic66 · 04/05/2024 19:44

That happened to me! I saw a faint at 9dpo and it was the trigger - was so disappointing so i think testing out the trigger is the best thing! i think with two it feels like atleast one should work! right?! What was your lining like? What cycle are you on? I'm on 2.5mg so i doubt i'd get 2 follicles.

It is my first Letrozole cycle and I was on 2.5mg. My lining was 8.5

Optimistic66 · 04/05/2024 20:37

@Letrozolelastchance

That's a brilliant response to 2.5mg - i was told at 2.5mg it highly unlikely to get
more than one follicle.

Ahhh all looks good 👏🏽

Letrozolelastchance · 04/05/2024 20:57

Optimistic66 · 04/05/2024 20:37

@Letrozolelastchance

That's a brilliant response to 2.5mg - i was told at 2.5mg it highly unlikely to get
more than one follicle.

Ahhh all looks good 👏🏽

i have a very high AMH (63.5) and quite a low bmi (18.5) I actually had to put weight on to get it up from 18, the goal was a bmi of 19 but not there yet but was given the go ahead and they did say that they expected a good response. I usually have very long cycles 35+ days and irregular and so this seems very strange to be so early and triggering I thought I’d need another scan next week !

dancingfairy1 · 04/05/2024 21:01

Hi, hope it's ok to join. Am new here!
I'm currently on an unmonitored Letrozole cycle (5mg without trigger). This is my 5th cycle on it.
Really hoping this is the one as I get terrible side effects from it! We only hit two days but hoping they were good days, am 6dpo today.

Daniki · 05/05/2024 09:20

Hey ladies can I join? Not on letrozole (done 4 cycles unmonitored previously no joy so doc switched me to tamoxifen and trigger shot. This is my second one and both times I tested trigger out. Today is 13 days past trigger and I'm still have vvvvvvvfl but they're not getting darker so I'm thinking lingering trigger or chemical 😩 I had 5000 in Gonasi so thought it would be well out by now!

Angelselevenx · 06/05/2024 08:05

Hey all,

Had a few weeks off the thread but moving onto cycle 3.

I was on 2.5mg for first round, brought ovulation forward by a day and extended my LP to 12 days.

2nd round 5mg, brought ovulation forward to CD18 and currently 15dpo with negative tests. My temp has dropped today so I'm expecting AF to be here later on. So glad it's extended my LP.

Round 3 I'm back on 5mg CD2-6 and I'm getting an internal scan CD9/10/11 (depending when AF shows) to check follicles and lining x

OP posts:
Daniki · 06/05/2024 08:17

Hi @Angelselevenx are you getting the trigger shot aswell or just doing letrozole?

Angelselevenx · 06/05/2024 08:18

@Daniki I ovulate on my own anyway so not doing trigger shots

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Letrozolelastchance · 06/05/2024 15:12

Did anyone else have absolutely no EWCM on their Letrozole cycle? I usually have loads (too much - over a week which apparently is due to oestrogen levels being too high?) but this month - nothing?? So now I’m worrying what if the trigger didn’t work?

Daniki · 06/05/2024 16:06

@Angelselevenx have you many side effects or anything from it?

@Letrozolelastchance I actually noticed that this cycle, think my trigger was timed wrong perhaps as I had none at all? Last cycle I had it the morning of my scan and the follicle was ready to pop! Had no scan this cycle he told me to trigger the same time as last cycle 🥴

dancingfairy1 · 07/05/2024 09:22

@Letrozolelastchance I'm on Letrozole (no trigger) but yeah I don't get much EWCM at all now! Which can make knowing when fertile period starts hard.
It is slightly better when I drink lots and lots of water but it's nowhere like what it used to be.

Daniki · 08/05/2024 06:35

Well AF came yest. I tested my trigger out,the lines never fully went away there were extremely faint even up until yesterday morning but I knew in my heart if it wasn't the trigger lingering it was a chemical. I think the trigger was gone around day8/9 as it was only the Gonasi 5000iu.
We have an appointment with the doctor at the end of this month about doing IUI so this will be our third and last monitored cycle, hopefully takes the pressure off!

Angelselevenx · 08/05/2024 11:29

@Daniki sorry to see AF came. My first round on 2.5mg I had headaches for 10 days.

Second round on 5mg no side effects.

Just started round 3 5mg so I'm hoping no side effects again!

OP posts:
Daniki · 08/05/2024 12:30

@Angelselevenx oh great no headaches second time round, I am dreading starting tomorrow because of the headaches 🙃 hopefully cycle 3 is lucky for us both! 🙏 I have read it takes 3 cycles for a lot of people

dancingfairy1 · 08/05/2024 20:04

@Daniki Interesting it takes 3 cycles!
Unfortunately we're on cycle 5 which is a failed one but for 2 of them they weren't timed right so hopefully this next final one will be successful!

BFN at 8 & 9 dpo so definitely feeling bummed as I do not want to go through those headaches again either.

Daniki · 08/05/2024 20:16

@dancingfairy1 I don't think mine was timed right either, have you the trigger shot too or just the tablets? I got scanned on my first cycle and then he told me to trigger on the same day of the next one, I had no EWCM or anything that day or before it so thinking it may have been wrong, but also think I may have had a chemical this month as I had barely there squinters up until yest!
Is your next step IUI? 8/9dpo so early so you're not out yet! When I was pregnant with my son I didn't get a positive until 12dpo and I am a POAS addict!

dancingfairy1 · 08/05/2024 21:56

@Daniki No trigger, just day 3-5 tablets 5mg. Only my first cycle was monitored and it looked normal - I already ovulate on my own but irregular cycles and Letrozole has made me consistently ovulate cd14.
Ever since we had our DD I barely have EWCM! And even less so on Letrozole which is hard. I hardly have any sex drive these days either so I can't rely on 'that' natural lubricant either.
Not sure what our next step would be... not quite ready to fork out for IUI or IVF yet but I'm sooo anxious about the age gap!

Daniki · 09/05/2024 06:25

@dancingfairy1 yea same, my son turned 3 last month and I'm really feeling that gap! You should try the mucinex method, it's all over tik tok 😂 will try it this month myself, supposed to help with CM.we use preseed as I find im as dry as the Sahara 😂🥴 I assumed I ovulated myself also as iv gotten pregnant 4 times but my progesterone levels were always on the low side at the day 21 blood tests so we said we'd try this!

Frankie2607 · 09/05/2024 08:35

Hi guys. I’ve been lurking on this thread as been waiting to start letrozole. Found out in March I had a uterine polyp (well, turned out to be 2), so had those removed a couple of weeks ago. AF has turned up today, so planning on starting tomorrow….
Feeling a little apprehensive but also excited to see what my body does. Really hoping this will help bring us our rainbow baby x

dancingfairy1 · 09/05/2024 09:20

@Frankie2607 welcome and good luck!

@Daniki Please tell me more?! Which ones, when do you start taking them/how often do you take them, and are there any other side effects??

Daniki · 09/05/2024 10:05

@Frankie2607 welcome and hopefully this cycle is lucky 🤞🏻
So the mucinex method is basically taking a cough bottle that contains guafinsen throughout your fertile window, as that ingredient thins the mucus in the body, so it will thin out cervical mucus aswell! Worth a shot, I have a cough anyway so hitting two birds with one stone 😂

Letrozolelastchance · 09/05/2024 19:17

Does anyone know when a hcg trigger shot (5000) should usually be out of your system ? I had it on Friday evening and testing daily but it’s still showing up the same on the easy at home strips I’m just hoping it’s out of my system soon !!!!

Daniki · 09/05/2024 21:33

@Letrozolelastchance usually by around day 10. If you divide 5000 by 2 per day it gives you roughly how much hcg should still be in your system!

Letrozolelastchance · 09/05/2024 22:09

Daniki · 09/05/2024 21:33

@Letrozolelastchance usually by around day 10. If you divide 5000 by 2 per day it gives you roughly how much hcg should still be in your system!

Thankyou ! The first 3 days the test was def getting lighter now it’s not changing much and I just want the trigger to be gone so that I know if I test in a week of the result is accurate !! I’m so impatient

Daniki · 09/05/2024 22:37

@Letrozolelastchance oh I know the feeling well 😝 I test it out to see if it goes negative cuz you know if it starts coming back it's a true positive!