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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Mounjaro / Tirzapetide January Starters

393 replies

Sebsaloysius · 02/01/2025 11:26

Anyone interested in a new thread for those of us taking the plunge this month?

OP posts:
Souredgrapes · 08/04/2025 10:54

@MathsMagpie . Let me know how it goes on 10mg . I stuck on 7.5mg as I felt it took me to the edge of feeling “normal” . Re the exit strategy ? Good question. Every diet I have done , I’ve put weight back on . So if I do , I can’t say it MJs fault .
i do hope to stay on the medication long after goal . I understand it’s possible on a maintenance dose . I just haven’t e mailed my prescriber and asked how to go about it . For now I’ll just keep ordering until they question me.

Re your goal of 10 stone. That was mine too as I didn’t feel I could possibly go lower . Turns out I could and i just kept going. I’m glad I did as I’m now 9 stone and feel much better for it . I’m 5ft 4 if that helps . This is where I want to be long term .
Good Luck ! X

MathsMagpie · 09/04/2025 16:53

Smallest loss so far this week but a pound is a pound so I’ll take it! The move to 10mg yesterday is kicking my butt - exhausted and felt sick all day but that could be school holidays and the sun! 7.5mg didn’t curb the hunger like 2.5 and 5 seemed to do..

SW 221.3lbs / 15.8 stone

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)
Week 9 183.4lbs (-4.4lbs)
Week 10 180.4lbs (-3lbs)
Week 11 177.4lbs (-3lbs)
Week 12 174.8lbs (-2.6lbs)
Week 13 173.8lbs (-1lb)

Total loss 47.5lbs

Souredgrapes · 10/04/2025 08:01

Yup , a pound is a pound. I didn’t lose this week but not was I was expecting too . I just want to stay steady now. What I did find mid way through the whole weight loss thing was if I had small loss one week , it was usually followed by a bigger loss the following week.

BonkersBaddies · 10/04/2025 08:01

MathsMagpie · 06/04/2025 09:22

@BonkersBaddieswhat’s your goal? Well done!

Hi! Goal is 'under 9 stone', so 8 stone 10, or 8 stone 12. I think I'll shift to maintenance at 8 stone 12 and see what happens. If I drop down to 8 stone 10 or a little under when on maintenance thats fine, but I don't want to go lower than 8 stone 7 as that's getting a bit too close to falling off the healthy weight range and almost entering underweight.

It's hard to know what maintenance will be like and whether I'll keep loosing, or gain a bit or what might happen! Not sure how easy/hard it will be to maintain a constant weight...

I'm scared of regaining the weight but also scared of going too low!! Feels like a fine balancing act but I'm seeing 9 stone as my 'dont go above' for maintenance and 8 stone 7 as my 'definitely don't go below'.

It's weird because I've never got as far as maintenance on a diet before!! so its a somewhat scary unknown!! I don't want to cock it up.

BonkersBaddies · 10/04/2025 08:03

MathsMagpie · 09/04/2025 16:53

Smallest loss so far this week but a pound is a pound so I’ll take it! The move to 10mg yesterday is kicking my butt - exhausted and felt sick all day but that could be school holidays and the sun! 7.5mg didn’t curb the hunger like 2.5 and 5 seemed to do..

SW 221.3lbs / 15.8 stone

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)
Week 9 183.4lbs (-4.4lbs)
Week 10 180.4lbs (-3lbs)
Week 11 177.4lbs (-3lbs)
Week 12 174.8lbs (-2.6lbs)
Week 13 173.8lbs (-1lb)

Total loss 47.5lbs

Well done 👍 👍

MathsMagpie · 12/04/2025 09:13

Still feeling awfully unwell on 10mg. Felt sick every day and awful stomach pain.

Upperroom · 12/04/2025 10:30

Thanks so much for the new thread @Sebsaloysius its lovely reading all the updates. I won’t be leaving anytime soon!! I think I’ll need this group for checking in and working out maintenance. It’s funny so many of you are quite tall. I’m 5’5’.

my ds is back in hospital which has been hard and a real juggle. Not to be too gushy but I’m still so grateful for this medication. I feel free of the emotional torment of, ‘where can I get chocolate, wine - basically sugar - my ‘fix’?’ I know this might sound strange when my child is in hospital. Not having the sugar crashes are so nice… especially with the added worry I suppose of a sick child.

I have also found I’m not so interested in watching tv lately. There’s not the dopamine hit there either - I wonder if anyone else has had the same? So interesting ?!

i’m not going to up my dose now - 7.5 is my max. I’m not interested in wine on this dose and I’m quite near my GW so I’m thinking of decreasing and then perhaps staying at 2.5 fortnightly. But I’m not completely sure yet…

Started Jan 20
SW 12ish st
CW 9st 8lb
GW 9st - but I’ve never been slim in adulthood - I’m hoping this weight would be a size 10 and absolutely no thigh rub. I’m an inverted triangle- thought I was an apple but actually my shoulders are broader than my hips. I need new bras! My E cups are very empty! No time to go shopping though - not sure if I need to go down a back size either - tricky need a fitting but dh and I are tag teaming with our other children 🤯

Souredgrapes · 13/04/2025 19:47

Hi @MathsMagpie . Sorry to hear this . 7.5 is as high as I can go . I tolerate it but 3 out of 7 days I do feel icky and eat very little but I do eat. Perhaps you will adjust , I find every week a bit different . This week the med took a few days to kick in , more than usual . I’m due my next dose Tuesday but feeling g like I do now , I may delay a day .
@Upperroom . Thanks for your post . Sorry to hear about your child. Wishing you all the best to get through. I will take time to re read again tomorrow because I really did relate to a lot of what you said . X

MathsMagpie · 13/04/2025 20:21

I’m definitely not going to take another dose of 10mg, it’s put me off having any ever again which is probably dramatic but it’s really knocked me. Not sure what I’ll do on jab day Tuesday.

tinyemmy · 14/04/2025 07:27

Upperroom · 12/04/2025 10:30

Thanks so much for the new thread @Sebsaloysius its lovely reading all the updates. I won’t be leaving anytime soon!! I think I’ll need this group for checking in and working out maintenance. It’s funny so many of you are quite tall. I’m 5’5’.

my ds is back in hospital which has been hard and a real juggle. Not to be too gushy but I’m still so grateful for this medication. I feel free of the emotional torment of, ‘where can I get chocolate, wine - basically sugar - my ‘fix’?’ I know this might sound strange when my child is in hospital. Not having the sugar crashes are so nice… especially with the added worry I suppose of a sick child.

I have also found I’m not so interested in watching tv lately. There’s not the dopamine hit there either - I wonder if anyone else has had the same? So interesting ?!

i’m not going to up my dose now - 7.5 is my max. I’m not interested in wine on this dose and I’m quite near my GW so I’m thinking of decreasing and then perhaps staying at 2.5 fortnightly. But I’m not completely sure yet…

Started Jan 20
SW 12ish st
CW 9st 8lb
GW 9st - but I’ve never been slim in adulthood - I’m hoping this weight would be a size 10 and absolutely no thigh rub. I’m an inverted triangle- thought I was an apple but actually my shoulders are broader than my hips. I need new bras! My E cups are very empty! No time to go shopping though - not sure if I need to go down a back size either - tricky need a fitting but dh and I are tag teaming with our other children 🤯

I'm 5'1.5 and currently 9st 1.5 I want to get down to 8st 7 or perhaps 4. I was regularly on or below 9st in my 30s but struggled to get to 8st 7 and in recent years piled on the weight whilst trying to get lower.
I am hourglass with big arms and big legs, my waist is tiny but I still have a C section pouch so I know I still have a way to go before I'm happy.
For me the binge eating has gone. I don't think I will come off mj as I don't want that back, but I will struggle to maintain on my current dose of 5, although I've eaten this way since 2.5 so who knows I'm sure some of it is psychosomatic but I never want to be large again. It is very close.

Choux · 14/04/2025 13:36

MathsMagpie · 13/04/2025 20:21

I’m definitely not going to take another dose of 10mg, it’s put me off having any ever again which is probably dramatic but it’s really knocked me. Not sure what I’ll do on jab day Tuesday.

Looking at your week by week losses you had plenty of weeks on 5mg and 7.5mg where you were losing 3-4lbs. That’s a lot to lose week on week at your current size so there was definitely a case for staying on something between 5mg and 7.5mg. If I were you I would consider dropping back to 5 for a couple of weeks to reset and then, if losses are a lb a week or loss considering taking the dose back up. If losses are 1.5lbs or more a week I would stay on 5mg.

Either way I would be looking to reduce what I was losing each week - it gets harder to maintain the losses anyway as your energy burning reduces as you get lighter - and focus on building sustainable food and exercise habits as you do the last stage of your weight loss loss.

MathsMagpie · 16/04/2025 09:55

Absolutely I’m dropping back down to 7.5 from today.

SW 221.3lbs

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)
Week 9 183.4lbs (-4.4lbs)
Week 10 180.4lbs (-3lbs)
Week 11 177.4lbs (-3lbs)
Week 12 174.8lbs (-2.6lbs)
Week 13 173.8lbs (-1lb)
Week 14 171.5lbs (-2.3lbs)

Total loss 49.8lbs

Mb76 · 20/04/2025 12:19

Hello, I’m a new poster here although I’ve been lurking here for a while. I’ve started back in January mid month. Did two months on 2.5 mg, then moved onto 5mg. My weight loss has been slow but steady between 1 and 2 lb per week. I’ve lost just under 2 stone so far and need to lose at least 5 stone more so I’m in this long term.

I haven’t seen anyone here mention the injection site reaction side effect which I have sadly developed on my second 5mg dose. Has anyone else developed this? On days 2-5 it grows bigger and bigger, not massively painful but hot and itchy, regardless of which injection site it is at. I am about to move on to 7.5mg and am a bit worried. I have reported this to my provider but they don’t seem concerned, apparently one in ten people develop reactions. The benefits for me outweigh the discomfort but I wonder if anyone has some useful tips on how to manage this particular side effect. Thanks in advance.

SilenceInside · 20/04/2025 12:27

@Mb76 I have seen people mention that getting a longer needle than the standard 4mm ones can help, you can get 6mm or 8mm ones which are still considered subcutaneous. Might be worth a try.

Mb76 · 20/04/2025 12:46

SilenceInside · 20/04/2025 12:27

@Mb76 I have seen people mention that getting a longer needle than the standard 4mm ones can help, you can get 6mm or 8mm ones which are still considered subcutaneous. Might be worth a try.

Thank you. I use a slightly longer needle for the bonus doses, it hasn’t made any difference sadly. I hope it may settle on its own as they say it can. Antihistamines help a little with itching. Some American forums say steroid cream helps but I am unsure we can get this in the UK.

SilenceInside · 20/04/2025 12:50

You can get HC45 cream which is a mild steroid cream, usually you have to ask at the pharmacy counter to get it.

Mb76 · 20/04/2025 13:02

@SilenceInside thank you, I’ll try that 🙏

DesperatleySeekingWeightLoss · 20/04/2025 18:23

Hi everyone! I joined this thread when it first opened, started on MJ mid-Jan. I’ve not popped on here much, but have been reading through your comments and wow, you are all doing so great ❤️❤️

I have a question, I’ve had the flu for 4 days and totally bed-ridden. Haven’t eaten anything at in 3 days because I’m feeling so nauseous. (I’m still on 5mg by the way so not due to a dose increase). But I think the nausea is coming from the flu meds. It’s not documented but does anyone know of adverse interactions between MJ and flu meds?

MathsMagpie · 23/04/2025 06:38

Happy Wednesday

SW 221.3lbs

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)
Week 9 183.4lbs (-4.4lbs)
Week 10 180.4lbs (-3lbs)
Week 11 177.4lbs (-3lbs)
Week 12 174.8lbs (-2.6lbs)
Week 13 173.8lbs (-1lb)
Week 14 171.5lbs (-2.3lbs)
Week 15 169.5lbs (-2lbs)

Total loss 51.8lbs

Souredgrapes · 27/04/2025 08:07

Morning All . Another good week for you @MathsMagpie , well done .

I Feel like I’m at goal now. In all I have lost 4.5 stone since starting WLI in 2023 ( had a break when saxander was no longer available) . I’m 5 ft 4 and have stayed around 8 stone 8 to 8 stone 9 for a number of weeks now .
I contacted my prescriber and they are happy for me to continue on a maintenance dose of 5mg so long as my BMI doesn’t change significantly. I’ve taken this to mean does not go lower or if it starts to increase then they may consider a higher dose .

I have been really impressed with the support from my prescribers . Initially they said that they only offered a maintenance dose for people with a BMI of 22 or over . Some discussions regarding mitigating factors ( my age / my general health and my sedentary job ) and they are happy to let me continue on 5mg . I haven’t really developed a decent exercise routine yet so this was discussed and they have advised and encouraged I do something about this.

I go on holiday tomorrow . I have bought some fabulous new clothes and swimsuits and I have had my existing holiday favourites taken in . I even have a bikini which I may or may not wear at the grand age of 55 !

Technically , I’m due my last dose of 7.5mg before I leave but I haven’t decided if I will take it or not . I’m thinking yes for damage control but my DH want me to enjoy the food the champagne and the cocktails. Away for 10 days and as it’s a 5 star all inclusive resort I can see what he means but I’m nervous about blowing it . What are people’s thoughts ?

Choux · 27/04/2025 09:54

Personally @Souredgrapesi would take the 7.5mg before leaving and then only take another dose when back. The first few days you will have the support of Mounjaro so should be able to enjoy everything moderately. If you take notice of how much you eat and drink you will then be able to see if your consumption increases as the week goes on. It will be an experiment.

last summer I went on a two week trip to the US including a week long cruise. I dropped my usual 10mg dose to 7.5mg for the weeks I was away - I did inject on the trip. I came back 7lbs heavier. I lost it in 10 days back on the 10mg and back on my usual food regime but, because of my experience, I would want some Mounjaro inside me for most of the trip.

Have a great trip!

Souredgrapes · 27/04/2025 10:14

Thanks @Choux . I’ll likely take it Monday morning and do as you say , let it wear off over the tens day and start up on 5mg when I get back . If the pattern continues , I’ll hit peak suppression Wednesday to Saturday. That still leaves plenty of time to enjoy things either in moderation or a bit OTT if I feel like it . X

MathsMagpie · 30/04/2025 08:35

Another Wednesday already! I think my realistic goal here now is around 10stone, originally I said I’d be over the moon to drop down to 12stone. My bmi is at 30 for the first time in many years and whilst I appreciate this is tipping between overweight and obese according to bmi - I’m so happy! This has truly changed my life.

SW 221.3lbs / 15.8stone

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)
Week 9 183.4lbs (-4.4lbs)
Week 10 180.4lbs (-3lbs)
Week 11 177.4lbs (-3lbs)
Week 12 174.8lbs (-2.6lbs)
Week 13 173.8lbs (-1lb)
Week 14 171.5lbs (-2.3lbs)
Week 15 169.5lbs (-2lbs)
Week 16 165.1lbs (-4.4lbs) / 11.7 stone

Total loss 56.2lbs

Souredgrapes · 11/05/2025 09:46

Morning @MathsMagpie , back from my hols. How was last weeks weight loss ? You are doing brilliantly. I gained 3 lbs on hols but I’m fine with that . The food choices were amazing and I was able to choose a lot of salad and fish. It was probably the cocktails that did the most damage 🤣.
I have started my maintenance dose of 5mg …. Still a bit peckish so I’ll keep on eye it for a week or so and discuss going back up if I’m struggling .
Hope everyone well , including @choux .

Pasttheline · 11/05/2025 13:02

I haven’t posted for ages but I’m 40lbs down and feeling fab. Still got a lot more to lose, probably the same again but I’m well on my way. I lost 7stone through calorie counting and exercise during lockdown but was never able to maintain it and put half of it back on. I’m about half a stone away from where I left off last time. Need to start incorporating exercise back into my life. I walk a lot already but need to start lifting weight again so that’s tomorrow’s job! Happy Sunday everyone