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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Mounjaro / Tirzapetide January Starters

393 replies

Sebsaloysius · 02/01/2025 11:26

Anyone interested in a new thread for those of us taking the plunge this month?

OP posts:
Tubbytiger · 18/02/2025 19:40

Thanks @Pasttheline and @Usernamesarenoteasy . Sounds like another month on 5mg is the way to go! Very impressed with extra notch and 22lbs btw!

Souredgrapes · 18/02/2025 19:48

Hi . Good to read your updates. Weight loss slowed for me but still a steady downward drop ( 20 lbs since January 2nd ) . I’m hoping for a further steady 2 lb a week drop until my holiday at the end of April .

MathsMagpie · 18/02/2025 20:08

Souredgrapes · 18/02/2025 08:46

Similar here too @MathsMagpie . When do you go up to the next dose ? My Day 6 is tomorrow and already I feel I could eat a lot more than I do on day 1 to 4 . I’ve one more week on 5mg before moving up . Well done for not having the pizza . X

I had my third 5mg tonight so will be moving up to 7.5mg in 2 weeks.
Really hoping it helps kill off the end of week hunger Blush

TinyKittenPaw · 18/02/2025 20:28

I feel I’ve been quite lucky. Fourth dose of 2.5mg this morning. No side effects so far but, I’m worried that if I go for a second 2.5mg pen and 2 weeks in the suppression is gone I’ll wish if moved to 5mg.

After some helpful advice on another thread I’m going for a 5mg pen then using 2.5mg while it’s working then move up if I need.

might also mean that if I stay in 2.5mg there is an option for a fifth dose without syringing which I’m not sure I can do 😬

Titasaducksarse · 18/02/2025 22:19

After 6 weeks on 2.5mg and 13lb loss I moved up to 3.75mg
I toyed with 5mg but suppression is still there half the week so thought 3.75mg might give a few days more. If not will take full 5mg next week

Titasaducksarse · 18/02/2025 22:21

DesperatleySeekingWeightLoss · 07/02/2025 18:31

So a really terrible experience with MedExpress. I paid for the 5mg new pen 6 days ago (due to start that today) and the order is "waiting to be dispatched". I've contacted them
Multiple times and they've not responded. Avoid..

I've had opposite experience. Ordered 5mg yesterday at 525pm and pen delivered today at 1330pm.

MathsMagpie · 19/02/2025 07:58

Weigh-in Wednesday for me

SW 221.3lbs
Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)

Total loss 25.8lbs

Zempy · 19/02/2025 08:27

@MathsMagpie Living up to your name with the excellent stats! I am more of a literary animal, so let’s call it Weigh Ourselves Wednesday then it’s WOW!!! 🤩

Anyway, I had a tough week but still lost 2 pounds. Injected my second dose of 5mg last night.

SW: 13 stone 7
CW: 12 stone 3

I want to see an 11 on that scale! Stamps foot petulantly.

MathsMagpie · 19/02/2025 15:40

Love it @Zempy! Well done!!

Souredgrapes · 21/02/2025 07:23

Morning . 4th 5mg jab done yesterday . I have stayed the same this week . A bit disappointed as my calorie deficit was good. On reelection. A few too many cals went on wine not food this week so I could well be retaining a lot of fluid . I do feel bloated.

Souredgrapes · 21/02/2025 07:24

Reelection ? That was meant to say reflection .

MathsMagpie · 23/02/2025 08:13

The munchies have come back stronger and faster this week again Sad I started with such strong suppression in the first few weeks, maybe it's just my body now being more used to the medication? I jab Tuesdays and by Saturdays I'm a hungry hippo again Blush

Zempy · 23/02/2025 09:23

What dose are you on @MathsMagpie ? Maybe you need to step up?

I definitely feel my suppression wears off as the days after jabbing pass. The first couple of days I barely get 500 -800 calories in. Then steadily upwards to around 1000 by day 6. I think it’s normal? The only caveat is bloody alcohol messing up your system. I’m just not touching it now.

I am now week 7 day 5 and have lost one and a half stone off my starting weight of 13 st 7 lbs. It still feels like a hill to climb to get to a healthy weight but I will keep going.

Choux · 23/02/2025 10:09

@Zempy your starting weight was 189lbs. You have lost 21lbs. That's 11% of your body weight! Celebrate that!!!

Yes it's normal that the suppression wanes a bit on days 5-7. My weight is always lowest on day 4 after a few days of food suppression and eating less. The half life of Mounjaro is 5 days so it disappears from your system relatively quickly. I guess they say take weekly jabs as it's easier to remember when it's due but smaller doses every 5 days would keep the suppression more constant.

MathsMagpie · 23/02/2025 14:36

@Zempy I'll be taking my 3rd dose of 5mg on Tuesday. Definitely going to go up to 7.5 in 2 weeks. Weight loss is still fine just so much harder to be good towards the end of the week!
Keep going, you're doing amazingly!

@Choux smaller more regular doses is an interesting thought!

Souredgrapes · 23/02/2025 17:55

We all seem to be in the same boat re the suppression wearing off around day 4 -6 . Me too . I’m in 5mg ( 4th dose this week ) but I’m loathed to move up to 7.5mg as the suppression on day 1 ( evening ) to day 4 is enough to stop me eating altogether. I have a box of unopened 2.5mg in the fridge and I’m thinking of taking that Monday evenings so I was interested in reading the comments by @Choux who said more or less the same thing . What’s your thought @Choux ? Move up or top up ?

Choux · 23/02/2025 18:41

I have been on Mounjaro for (two weeks shy of) 12 months. You have all presumably been on it 1-2 months only. For the first two months I followed the box instructions to the letter (well except I always took the bonus dose as it makes the cost 20% cheaper.

I think you should all spend the first couple of months figuring out how your body reacts to Mounjaro and what is normal for you before you start deviating from the instructions. Having said that over the last 12 months I have:
Switched the injection day quite a few times - the instructions say you can move it by 4 days - in order to not be too suppressed when meeting friends (no one knows I have used Mounjaro except my brother (and my SIL) and one friend who are both on it too)
Gone up to 10mg, found the suppression too much so dropped back to 7.5mg and then gone back up to 10mg a couple of weeks later.
Taken 10mg as two 5mg doses 3-4 days apart - think this was related to seeing friends on what would have been day 1 of my injection when on 10mg.
Dropped down a dose for two weeks while on holiday - I put on 7lbs but lost it in 10 days once home.
Taken a bonus dose of about 0.8ml from the 15mg pen which was probably 20mg - had never had any adverse side effects on any dose so decided to just go for it. I was fine.

I am now tapering down as am at my goal weight so am on 10mg. Today is Day 5 and I am hungry. I won't need to eat a big portion as my stomach has shrunk but I am ready for dinner. I mainly did low carb to lose the weight. Now I am maintaining and eating more I am eating rice and occasionally bread and pasta I am convinced carbs are making me hungrier so I may try low carb this week and see if it helps curb my appetite. It's all trial and error.

MathsMagpie · 23/02/2025 19:00

@Choux that's really helpful, thank you for sharing.

Souredgrapes · 23/02/2025 20:28

Thank you @Choux .

MathsMagpie · 26/02/2025 07:01

It's that time of the week again!

SW 221.3lbs

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)

Total loss 29.1lbs

Zempy · 26/02/2025 13:51

I’m here! WOW

SW: 13 st 7
CW: 11 stone 13.

I am just starting week 8 but not jabbing until Friday night because of work commitments. I’m going to collapse on the sofa all weekend.

Suppression lasting a lot longer this week, my second 5 mg dose. Usually I am starting to eye up the biscuit tin at this stage.

Souredgrapes · 26/02/2025 19:01

Hi @Zempy hi @MathsMagpie . Good to see your stats on WOW 🤩. You have both dropped through some significant mile stones . My weigh day is Thursday but I always seem to hit my goal on a Saturday so perhaps I should move it or just join you guys on Wednesday . Wishing you lots of encouragement!

Zempy · 26/02/2025 19:07

Thanks @Souredgrapes . Yes I feel confident about changing my jab day this week, but other weeks I have really noticed the hunger creeping back. I hope your change goes well.

Good luck everyone.

MathsMagpie · 05/03/2025 07:23

Happy Wednesday!
I started 7.5 yesterday, feeling fine.

SW 221.3lbs

Week 1 211.8lbs (-9.5lbs)
Week 2 208.7lbs (-3.1lbs)
Week 3 206lbs (-2.7lbs)
Week 4 200.6lbs (-5.4lbs)
Week 5 198lbs (-2.6lbs)
Week 6 195.5lbs (-2.5lbs)
Week 7 192.2lb (-3.3lbs)
Week 8 187.8lbs (-4.4lbs)

Total loss 33.5lbs

Souredgrapes · 05/03/2025 07:56

@MathsMagpie , that’s brilliant progress , you must be so chuffed . What are you managing to eat in a day on 7.5mg?
I started 7.5mg on Sunday . No unwanted side effects . Suppression is really strong for both food and alcohol.

My weight loss is slow but steady , I switched to Mounjaro from Saxander so I’m ahead of you guys in terms of how long I have been using WLI . I’ve lost 24lb since starting in January. Goal feels close but at this slow rate it’s still a good month to two months away . X

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