He would probably not be too bothered but would be unlikely to find buddies to go out with.
Is that because he wouldn't choose to socialise with the opposite sex, or because you/he would assume that they wouldn't choose to socialise with the opposite sex? Sadly, you might be right if the latter. Although our three (2, 1F) have always had friends of the other variety, so to speak, it always ars me sad to read things like, My DD's reception class has 20 boys and 6 girls in it, so her pool of potential friends is very restricted ...