Hi panic,
The combined test has your age as a major variable in the formula; hence it always comes back worse than other tests if you are 42.
harmony looks at the cDNAs of the baby circulating in your body and is more accurate for the three trisomies, 13, 18 and 21.
I wouldn't worry about your combined test results if the harmony test couldn't detect the trisomy 21 in your child's cDNA.
CVS and amniocentesis look at the same pool of genetic issues and if you are having CVS then it is pointless to do amniocentesis!!