I am baffled as to how both of them are not mortified at their attitude/behaviour towards you. It's one thing to be scatty and forget to be hospitable momentarily if busy with something else, it's another thing entirely to completely blank you, not respond, and not be slightest bit bothered that they have no manners at all.
So there are (to me) two reasons for this -
One - there is a backstory. Only OP knows if there is, and if that is the reason.
Two (this is what I think), they have extra needs, both of them, whether that is full on neurodiversity or something else, their lack of social awareness is down to some brain issue.
How are the grandchildren?
It is difficult to give advice, since no one knows whether it's ND, a backstory, Mum's the issue, DIL/Son is the issue or what.
Whatever it is, it makes for a very uncomfortable and unwelcoming visit, and I can see why OP is very sad and baffled, but we don't know the full story. There has to be one, even if it is just thoughtlessness. I suspect it's more than that.