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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

So this is how normal people feel about food?!

155 replies

thatsginthough · 27/08/2026 02:35

Two days into my second week on Mounjaro 2.5.
Not once, since the day after my first jab have I actively thought about food. Mealtimes can come and go without it even triggering a thought in my head. I’ve already lost 5kg which is 15% of my target loss.
DH makes dinners so it miraculously appears. I enjoy it but after about a third of what I’d normally eat I’ve had enough. I then don’t think about snacks for the rest of the night.
Compared to before when food consumed my thoughts all day this is an absolute revelation.
I used to wonder how people could pace themselves at a buffet, not eat their entire plate in one go or sit with an open packet of biscuits on their desk. This must be how they feel. It’s amazing.

OP posts:
Stormyrose · 30/08/2026 13:21

Nellodee · 29/08/2026 11:11

I’m not a scientist, but this really doesn’t tally with what I know. Firstly, if it doesn’t become less effective, why do so many people need to keep increasing their dose? Diet fatigue cannot explain that away. If you have diet fatigue at 5mg, and you move up to 7.5 to overcome it, and it does, why would you ever need to move up again?

Secondly 7.5 now does not feel like 7.5 did when I first got to it. Or even after a couple of months on it. I can take 7.5 now and only realise very occasionally that I’m even on it, whereas I used to struggle to eat 1000 calories on it and had to move back down to 5 a couple of times because it was just too strong for me to function.

Lastly, just because something continues to work for diabetes (thank goodness) does that automatically mean that it will continue to work for weight control? I don’t think the one necessarily proves the other.

Ok, if if helps. Think of any medication for a condition. The optimal dose is different for everyone. For example I was on the max dose of two blood pressure meds. I started at the lowest.

this is because the lowest was not enough to control my blood pressure. It’s rhe same for weight loss injections, you move up till you find your optimal dose. And stay there, for me thay was 10mg.

it isn’t it wears off so you need more, it’s simply you’re not at the right dose for you, this is normal for all prescription medication. It is not rhe case everyone takes rhe lowest dose of whatever and then it stops working and you need to increase. That’s not how medication works.

however weight loss drugs are complicated by mental health. Because for many the placebo effect also takes place, which can be very real. People want it to work, think it is working, and thus it works, they decide their appetite is controlled and so it is. The mind is a powerful thing. Then diet fatigue sets in. And people start to feel the real effect, it’s why they feel it works less well second time round, as they don’t have the placebo effect . So the mind complicates it

but weight loss drugs don’t wear off. They don’t become less effective. So you need to increase, they simply behave like every other prescription medication where you need to find fne right dose for you

EvieBB · 30/08/2026 22:11

Stormyrose · 30/08/2026 13:21

Ok, if if helps. Think of any medication for a condition. The optimal dose is different for everyone. For example I was on the max dose of two blood pressure meds. I started at the lowest.

this is because the lowest was not enough to control my blood pressure. It’s rhe same for weight loss injections, you move up till you find your optimal dose. And stay there, for me thay was 10mg.

it isn’t it wears off so you need more, it’s simply you’re not at the right dose for you, this is normal for all prescription medication. It is not rhe case everyone takes rhe lowest dose of whatever and then it stops working and you need to increase. That’s not how medication works.

however weight loss drugs are complicated by mental health. Because for many the placebo effect also takes place, which can be very real. People want it to work, think it is working, and thus it works, they decide their appetite is controlled and so it is. The mind is a powerful thing. Then diet fatigue sets in. And people start to feel the real effect, it’s why they feel it works less well second time round, as they don’t have the placebo effect . So the mind complicates it

but weight loss drugs don’t wear off. They don’t become less effective. So you need to increase, they simply behave like every other prescription medication where you need to find fne right dose for you

Also you are not allowed to start on a higher dose straight away due to side effects like diarrhoea....you have to work up slowly to minimise side effects and many people don't start losing weight/feel the effects of the jab until they are on the higher dose.. so it's not the case that you have to keep increasing because it wears off

TheCountessofFitzdotterel · 31/08/2026 13:26

AWomanOfWealthAndTaste · 29/08/2026 20:37

I don't think saying normal when you mean not overweight is an accurate framing.

Because in societies where everyone has enough food, many have majority overweight populations and, at least pre WLIs, they virtually all had increasing obesity rates. It's not actually normal even to be successfully able to exercise willpower to stay slim throughout one's lifetime without appetite suppressants, let alone not to need much of it.

While I agree that normal isn’t the best term to use for not overweight, it’s important to recognise that the ever increasing obesity rates are a feature of society dominated by UPFs. It is not the case that historically, the rich and middle classes, who could afford enough food, inevitably piled on weight in the same way that we do today.
Some did (Henry VIII anyone?) but not to the levels we see in the modern world.
It’s not normal to be living in a society where foodstuffs scientifically designed to be highly addictive are constantly pushed at us. The human body isn’t the problem - the obesogenic society we live in is.

MoneyJo · 31/08/2026 13:41

The human body isn’t the problem - the obesogenic society we live in is.

This is a huge part of the problem @TheCountessofFitzdotterel I agree. Crap food is cheap and accessible all around us.

AWomanOfWealthAndTaste · 31/08/2026 15:23

TheCountessofFitzdotterel · 31/08/2026 13:26

While I agree that normal isn’t the best term to use for not overweight, it’s important to recognise that the ever increasing obesity rates are a feature of society dominated by UPFs. It is not the case that historically, the rich and middle classes, who could afford enough food, inevitably piled on weight in the same way that we do today.
Some did (Henry VIII anyone?) but not to the levels we see in the modern world.
It’s not normal to be living in a society where foodstuffs scientifically designed to be highly addictive are constantly pushed at us. The human body isn’t the problem - the obesogenic society we live in is.

It's also worth pointing out that there isn't a single example of a society that

  • had enough resources to feed the whole population as much as they wanted
  • didn't have a substantial minority (or more) of the population taking an appetite suppressant, be it nicotine or WLIs and
  • didn't experience increasing percentages of the population being overweight once this stage was reached

We do have an obesogenic environment in the UK, but we don't actually know it's the problem rather than one of them.

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