I was more physically exhausted than emotional for DD1. We left with the maximum baggage allowance (two full to bursting suitcases each) plus cabin bags, up at 3.30am for a 6am flight across the US, changed planes once with a short layover during which I ate a bagel, then up in the air again, then a taxi to the train station, then a long ride to the city, then another taxi. I had half an hour to drop DD's bags in her dorm room, nibbled two cubes of cheese and a few crackers at the parent reception, kissed DD goodbye. I then caught a taxi back to the station, got the train, nodded off a bit, taxi back to the airport took a detour to a strip club with one of the passengers (there were three of us) who was owed money there, apparently. The remaining two of us threw our money at the cabbie as we shot out of the cab when we finally got to the airport, and just about made it to the last flight out. I got back home at about 1.30am. The rest of the DCs started back to school the next day, so no rest for the wicked
For DS, we all drove seven hours to his university, dumped his stuff in his room, hit the local Walmart for extension cords and a few other sundries, got soaked to the skin in a tropical downpour, and had a very weepy goodbye when we returned to the campus. Then drove seven hours home. The first half hour was silent apart from little sniffles from everyone. DS cheered up after a week but eventually transferred to a closer and much better university, so a win all around.
More exhaustion and also an injured back when dropping off DD2. Drove fourteen hours on a Friday with the car stuffed to the gills with her earthly belongings, stayed with DD1 overnight, toured the city next day, slipped and fell on wet paving, hobbled around the rest of the day, got DD moved into her dorm at the appointed evening hour with help from DD1, slept at DD1's place that night, and headed home (another fourteen hours) on Sunday, taking as much tylenol as I could safely take en route.
Remaining DCs went local (phew).
The really big break happens when DCs graduate and get a job away from home, with no more long summer vac.