I think reaching perimenopause definitely made me lose my generic, conditioned "be kind" filter, of younger years. 
And I was a kick ass feminist, in a male dominated profession, seen as a trailblazing woman during my entire working life.
Yet still, conditioned, apparently 
Yes, of course I was still kind, but only when it was warrented.
And yes, it infuriates a lot of men.
Hence the hate aimed at so called "dried up old hags"
etc, who no longer gaf. You only have to see some of the vitriol aimed at women of a certain age, on Twitter 
But it could just be an age related thing, rather than hormonal?
After all, by around 45 - 55 ish, perhaps women have just had enough of the #bekind stuff?