https://pmc.ncbi.nlm.nih.gov/articles/PMC11411746/
'There are no guidelines for induced lactation in transgender women, so we increased the hormone dosage based on periodic blood tests and patient symptoms. At the time of the treatment of the current patient, there had only been two previous transgender breastfeeding papers 6, 7]. Therefore, although estradiol, progesterone, and prolactin were monitored with reference values, it was difficult to evaluate the test results. Because of concerns regarding leg vein thrombosis associated with high-dose estrogen, and arrhythmia and dyskinesia associated with high-dose domperidone, the lower extremities were carefully visually inspected and examined neurologically, and ECG was regularly monitored. Blood tests were performed as an adjunct to screen for thrombosis by measuring D-dimer.'
What about the baby?
'Considering age and other factors, the risk of estradiol-induced venous thromboembolism was considered high, and transdermal rather than oral agents were chosen for estrogen administration, as recommended in the guidelines 12]. The initial milk production was only a few drops. Subsequently, 8 mg estradiol, 500 mg progesterone, and 80 mg domperidone were administered to continue pseudo-gestation. We did not increase estrogen and progesterone levels to gestational and postpartum levels because of the risk of venous thromboembolism, and because milk production was observed, the levels of estrogen and progesterone were simply maintained. '
'On day 146, [his] partner delivered and the patient was able to directly breastfeed the baby. After consultation with the patient, domperidone was tapered and breastfeeding was discontinued on day 237, 3 months after delivery. The breastfeeding period was physically and psychologically taxing for the patient because of the ongoing hypoestrogenic and hyperprolactinemia associated with drug adjustments. Considering the patient’s age, health, and the burden of raising a newborn, breastfeeding was discontinued. '
WHAT ABOUT THE BABY?
...
'The current patient was older, obese, and had high insulin resistance, which may have contributed to delayed/poor lactation. Other reports did not mention the body mass index. The current patient was in [his] 50s, which is older than other cases. It has been suggested that obesity may increase insulin resistance, resulting in delayed induction of lactation 17, 18], although the mechanism is still unclear.'