Microdose tablet form of GLP1

[ForFairGreenWriter]

Hello . I'm wondering if there is anyone who is microdosing the GLP1 TABLET .
I'm really interested in doing so , but have come up against " why you shouldn't / can't / etc !)
However ! apparently there' ARE some people doing so effectively but I just need to find them !!
Thanks 😊

How does this work, they can’t be cut

What do you mean by microdose? I'm on the 1.5mg pill which is the lowest one produced I think? As a PP said they don't work if you cut them up.

I've not actually seen a physical tablet , have you ? but I have a pill cutter and regularly cut up my other medication very accurately ( with doctors consent )

I've come across comments online whereby people do apparently cut the tablet up effectively and are successful doing so . I'm just trying to actually find someone who is doing it and what they have to say .

The tablets have a specialised coating in order to make sure that the medication is absorbed as optimally as possible in the stomach. Cutting the tablet means that coating won't be as effective and less of the medication gets into your system.

Yes , I have heard this too . I'm just curious though , about those who still actually do so ( apparently ) effectively .
At the end of the day , the companies making these medications , don't want people using these sparingly ( and effectively ) because ultimately , they lose money .

I mean, if you think it's a conspiracy to make you spend more money, then crack on and split the tablets up and see what happens. Why ask anyone about it?

Semaglutide is very quickly destroyed by stomach acid. Only about 0.8% of the medication in the tablet makes it into your bloodstream. The specialised coating, called SNAC, protects the medication and helps with absorption. From the Wegovy website:

"SNAC (salcaprozate sodium) is included in every Wegovy® pill. It allows the medicine to be taken by mouth once daily because it helps the medicine survive in the stomach long enough to be absorbed into your bloodstream. Technically, SNAC protects the medicine from acid and enzymes in the stomach and temporarily increases local absorption through the stomach lining so the medicine can reach the circulation when taken by mouth. Without SNAC, almost none of the medicine would be absorbed from the pill so there would be no treatment effect." https://www.wegovy.com/obesity/starting-wegovy/starting-wegovy-pill.html

Or, use Foundayo, which doesn't have this specialised coating and does not need to be taken with the same restrictions as Wegovy tablets. Sub-dosing those would not have the same issues.

I mean nothing to be lost by trying I guess. The tablets I have are teeny though it would be fiddly.

You can’t cut them as previous post says it ruins the coating. There’s mixed reviews online but people doing this appear to be on the highest dose therefore it’s arguable that enough semaglutide is in their system. If you wanted to microdose them taking every other day would be better than cutting

The way I read it, SNAC is not a coating as such but is integrated throughout the tablet. But not necessarily equally throughout it.

The way it works is the tablet is designed to land on the stomach lining and create a little environment where it neutralises the stomach acid (which would destroy the semaglutide immediately, before it is absorbed) around it, it also increases the permeability of the stomach lining locally where the tablet lands to allow it to absorb the semaglutide.

Cutting the tablet will disrupt the carefully designed tablet shape, possibly impact the amount of SNAC you have if not equally distributed, exposes the raw inside of the tablet early and potentially gives you erratic absorption.

Obviously it’s not going to be harmful if you try it, but it doesn’t sound as reliable a cost saving solution as liquid injections.