UK first in Europe to authorise orforglipron (Foundayo)

[WeAllHaveWings]

For anyone interested

https://www.gov.uk/government/news/uk-first-in-europe-to-authorise-orforglipron-for-weight-management-and-type-2-diabetes

I saw this. Potentially interesting as a maintenance option, depending on price

I saw this with interest too. Wondering when prices will become available…

Though I hadn’t spotted this is just a GLP1 and not a GIP. I think it’s the GIP “bit” that has been good for me…

Interested to know if you can swap to this if you’ve been on mounjaro or wegovy or if it’s just for diabetics and people with bmi 30 or 27 with two conditions. And if it’s just for those with those criteria if it will likely change

I saw something yesterday which said starting price was estimated at 79 pounds a month, which makes sense as it is signifantly weaker than the wegovy pill which starts at 99.

With wegovy pill you can swap so assume this will be the same.

@tobee as far as I can tell Foundayo / Orforglipron has been given the same approval for use in the UK as the Wegovy tablet.

I don't know this for certain, but I would think if you can evidence that you have taken Wegovy or Mounjaro injections then a private prescriber should be willing to take you on to maintain using the tablets, rather than injections. I can't see why they wouldn't.

👍

Patient leaflet now published with doses

Foundayo® 0.8 mg film-coated tablets

Foundayo® 2.5 mg film-coated tablets
Foundayo® 5.5 mg film-coated tablets
Foundayo® 9 mg film-coated tablets
Foundayo® 14.5 mg film-coated tablets
Foundayo® 17.2 mg film-coated tablets

https://www.medicines.org.uk/emc/product/102527/pil

Can you explain the difference between the two please? Is GLP1 the food noise part or is that the GIP? I need something to shut that part up, then dig it a grave sixty miles away.

I am the same re: food noise. I’ve lost nearly half my body weight and replaced my sugar addiction with exercise, but it’s being free of the food noise (regardless of weight loss/fitness gain) which is my greatest win from my time on Mounjaro.

I had a quick look to see if there was a good summary article, but couldn’t see one. If anyone has a good source, feel free to replace my clumsy explanation!

My understanding is that the GLP-1 works on the slower gastric emptying which makes you feel fuller/eat less, whereas the GIP targets the metabolic pathways which regulate insulin production/sugar regulation, fat storage and the reward pathways in the brain. So they work really well together, but for me, it’s the latter which has been the breakthrough. I understand that the next generation of drugs will target even more areas/pathways.

Quite how that exactly relates to food noise I believe isn’t totally understood, maybe because it’s highly personalised. But to me, as a layperson, it makes sense that it my blood sugar is stable and brain thinks it’s getting the nutrients it needs, my body will be happy and won’t obsess about food 24/7. Have a listen to the “fat science” podcast… I love how they make the science behind it all accessible.

Hope that helps and someone feel free to correct/expand!

@Questions1234 thank you so much for the explanation and it looks like I will need the GIP more as well. I overeat for too many reasons and non are hunger.