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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

2.5mg to 5mg worries

17 replies

smileymileysmiley · 29/08/2025 07:53

Have done 4 weeks on 2.5mg with no symptoms at all. Mild suppressions and im not bingeing anymore but not really losing weight - so have have 5mg now but have been reading about people with awful symptoms and abit scared! I am away with work mon-wed and jab due today

would you wait and do after or is it unlikely i'll get symptoms as nothing so far?

any advice appreciated

OP posts:
ellieinfrance · 29/08/2025 08:00

I was really nervous about moving up to 5 due to hearing horror stories, and was totally fine. Be a bit proactive about it, drink enough water, then more water and eat something more basic than vindaloo style! But I'd just get on and do it. If you're not away until Monday anyway, even if you do react, you may well settle by then. Good luck!

SunandMoor · 29/08/2025 08:02

smileymileysmiley · 29/08/2025 07:53

Have done 4 weeks on 2.5mg with no symptoms at all. Mild suppressions and im not bingeing anymore but not really losing weight - so have have 5mg now but have been reading about people with awful symptoms and abit scared! I am away with work mon-wed and jab due today

would you wait and do after or is it unlikely i'll get symptoms as nothing so far?

any advice appreciated

If you do it today you will likely get over a reaction over the weekend. I had no symptoms with 2.5mg and none on 5mg. You could hedge your bets and go up to 3.75 out of your 5mg pen which is 45 clicks.

ResusciAnnie · 29/08/2025 08:03

I’ve just gone up to 5, no side effects really other than a dodgy tummy after I ate some greasy food (sausage roll and some crisps so to be expected really!).

The suppression is huge though, I could go a couple of days without getting hungry. So I don’t want to get used to that, as obviously very unrealistic and unsustainable. And unhealthy. So thinking I’ll do a 3.75 for a while, especially given the price rises.

ScoffingWaters2000 · 29/08/2025 08:28

I did 3.75mg from my 1st 5mg pen as I was also worried about side effects, stayed on that dose for 2 weeks and then moved up to 5mg, I’ve done this for all my ‘titrating’ and it worked well until I moved from 7.5mg, I did my 1st jab using the ‘golden shot’ and went up to 9.5mg as I was using up the last of my 7.5 pen, I was really nauseas, tired and dizzy for the rest of the week, so I went back down to 8mg, all ok again, then did, 8.5, now on 9, taking it slowly works for me I guess, just wish that I could apply that to my spending on Vinted!

RockChik · 29/08/2025 09:33

I was also nervous so did 3.75mg for the first couple of weeks. After the second one I felt the suppression wore off quickly so did another 2.5mg on day four which ended up being a bit too much!

smileymileysmiley · 29/08/2025 16:11

oh god it's so hard to know! how many clicks is 3.75? presume the pen lasts longer then? need to jab tonight and in 2 minds as out earky monday and have flights and travel and no time to be ill

OP posts:
reluctantbrit · 29/08/2025 17:34

I moved up last week and felt sick for around 48 hours. I could eat but only bland and small portions.

Strangely enough I was really hungry from day 5. I just jab for the second time on 5mg and see what happens.

I also didn't loose a lot compared to previous weeks.

L4ura171986 · 30/08/2025 08:11

I am on 5mg. That first week was awful. The worst nausea and eggy burps and explosive diarrhoea but… this all settled down and now I tend to get one day of mild loose stools and the occasional eggy burp.

kiwiane · 30/08/2025 08:32

I reckon it’s 45 clicks for 3.75 as it would be 60 for a full 5mg dose with your pen.

NotifyThe · 30/08/2025 08:57

If you are worried then don't go up the full amount.

It is highly likely that the 5th dose in your pen will be more than 2.5 mg, if you take it all. I got 0.76 ml, which is 3.2 mg. I would just do that next week and see how you feel (that's what I did).

The following week I did 50 clicks of the 5 mg pen (4.2 mg) - I was very suppressed on this but no side effects other than that. Holiday next week so decided to stick there for another week. The following week I went up to 55 clicks (4.6 mg) - this was too much and I had side effects that were quite bad the entire week, do I dropped down again. This cycle happened twice. See graph for what I did...I thought I would slowly transition up to 5 mg over 4 weeks, in reality it took me much longer that!

In hindsight I would do whatever the 5th dose that is in the 2.5 mg pen. If that is fine then go up to 45 clicks (3.75 mg). Really pay attention to your suppression - do not go up if you don't need to...(unlike me!).

Most people are fine going from 2.5 mg to 5 mg. If you are worried I would definitely go the more cautious route though (I am very glad I did, even though I still made a mistake with it - twice!).

2.5mg to 5mg worries
threeeggsontoast · 30/08/2025 09:11

I use the Shotsy app which gives an indication of how much MJ is in your system. It does actually build up in your system so after a month on 2.5mg, in the first 24 hours after you jab, you’ve likely got around 3.5mg in your system anyway. So a jump to 5mg isn’t really that much of a leap.

When I moved between doses I was totally fine as well. Next month I’m likely going to move up to 7.5mg. I usually jab on a Saturday but I’ve got an event that day, so just to be safe (in case there’s any side effects), I’ll wait till the Sunday to do it.

deblcouen · 30/08/2025 09:14

I would stick with 2.5mg and look at what you are eating if not losing weight. You need to be in a healthy calorie deficit.

Motnight · 30/08/2025 09:21

I'd use the golden dose in the 2.5 mg pen personally. If I recall correctly when I went up to 5 mg I didn't feel great the first week.

reluctantbrit · 30/08/2025 11:43

I did my second 5mg jab and feel fine this time.

But my constipation is back 😭

smileymileysmiley · 30/08/2025 16:37

thanks everyone - i've hedged my bets and gone for 3.75 as need to be ok for work travel. So far is ok!

OP posts:
TheyCallMeStacey · 30/08/2025 16:56

I’ve stuck at 3.75 for seven weeks and only just increased today to 4.2 (50 clicks). My weight loss has slowed but still gradually going down so happy to take it steady.
I don’t know if it’s because I’m getting closer to goal but it does feel slow!

KnewYearKnewMe · 30/08/2025 17:29

Good idea OP.

i moved up to 3.75mg first - no real side effects, and I think I stuck on that for about 12 weeks before moving to 5mg.

I’m now taking 9mg - almost 5 stone down over 10 months,

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