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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

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Original poster

Disappointed with first week of mounjaro

36 replies

Roxietrees · 17/06/2025 11:44

I had my first 2.5mg injection of mounjaro 3 days ago. I don’t have side effects but my appetite isn’t very suppressed. I do feel a little less hungry and have cut my calories a lot but it’s quite a lot of effort. I think reading all the positive stories on here I got my hopes up thinking I’d just not feel hungry at all straight away. I know it’s only been 3 days but I expected a lot more appetite suppression. Anyone else experiencing this? Does it get better when you go up to 5mg?

OP posts:

FortyElephants · 22/06/2025 11:27

Are the 'loads of people' people you've seen on TikTok by any chance?
Of course you aren't going to get immediate effects on the drug. Very few people genuinely do. For me I got a placebo effect straight away but I know it was placebo because once the genuine suppression kicked in it was very noticeable. When I felt full in the first few days it was because I was hyper aware of feeling full and didn't push past that feeling like I usually would to finish my meal. A small number of people are super responders and they lose lots of weight on low doses but that's RARE.

12purplepencils · 22/06/2025 11:49

Give it time. Loads of people out there who didn't feel effects straight away, including me. A year on and I've lost 20% of my body weight. There's no rush.

ThatHappyGreenDreamer · 16/06/2026 12:47

Just had my first dose of Mounjaro yesterday. When do side effects start to kick in?

SilenceInside · 16/06/2026 12:55

@ThatHappyGreenDreamerany time between now and never! More helpfully, the medication reaches its peak in your system anywhere between 8 and 72 hours after injecting. Side effects, if you get any, can be associated with that peak of medication.

reluctantbrit · 16/06/2026 16:35

Lostuser · 17/06/2025 14:26

I’m about 3 months in and I’ve barely lost any weight, I’m persevering with it until the end of the end of the year. Just going up to 1 mg so 🙏🏻

You are microdosing with 1mg? Honestly that is absolutely pointless.

Do a proper 2.5mg and then move to 5mg if you want to loose weight.

TheBlueDeer · 16/06/2026 17:21

I had effects almost immediately. Surprised to see people saying they didn’t. You may have to wait until the 5mg pen as that’s the therapeutic dose

HappyWineDay · 17/06/2026 12:22

Kinkyroots · 17/06/2025 14:18

I’m 4 weeks in on 2.5 and have significant suppression along with feeling full very easily. I have 5mg ready to go but am wondering now if I should stay at the 2.5 until it isn’t doing it? I lost 8lb in the first 2w, don’t know what now as on holiday overseas. Have felt nauseous a couple of times, and got very shaky when I don’t eat when I do get hungry, but honestly, I feel like I’m a different person. Really odd, in a good way.

If 2.5mg is working for you then there's no reason to increase your dose.

SpiralSister · 17/06/2026 20:17

ShrankLastWinter · 17/06/2025 21:29

It’s better to think of it as satiety rather than suppression. You are likely to still get hungry for meal times, but you should also get fuller faster. It is crucial to eat protein because this gives you more and more lasting fullness.You also need to eat slowly and mindfully.

But as everyone else has said, it’s only been 3 days! Some people have strong effects on 2.5, stay on it for weeks and lose a pound or two every week. Some people need to go up faster.

As you said, you are feeling a bit less hungry and have been able to cut your calories a lot. So it is in fact already helping you.

Absolutely this. Appetite suppression is a side effect that not everyone will experience. Satiety is what you are aiming at. This will mean you eat less than previously. Hunger should not disappear - but you should be able to feel fuller for longer.

You might not experience that until you are at a considerably higher dose than 2.5mg. But you probably will and in a month or 2 will be losing weight.

Your provider will have told you all this of course - as long as you have gone with a legitimate source!

TheBlueDeer · 17/06/2026 20:27

I have absolutely no hunger at all but if I choose to eat I can, I’m not getting full on less food or anything like that. I feel bored eating though so can’t finish a meal.

EdinaTheConfessor · 17/06/2026 20:39

I’m a fast responder. I lost my appetite pretty much straight away, and same again since I have been back on 2.5 for maintenance after a 6 month break.

BUT I believe that isn’t the case for anyone and 2.5 is only meant to be an introductory dose to get your body used to the medicine. 5mg and up are the therapeutic doses. Do don’t feel disheartened, keep going. It will work eventually.

Sirenee · 17/06/2026 20:54

It's not unusual no, most people have to get up to the highest doses for it to be effective, the smaller doses are to get your system primed,I however felt it almost immediately and lost a lot of weight on 2.5 ,it just depends how sensitive to it you are.

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