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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

SSRI and Mounjaro - anxiety returned

5 replies

Mounjaroscarednewbie · 20/01/2025 14:49

Ok… so the first few weeks on Mounjaro, I felt pretty good , anxiety wise . I felt it calmed me down significantly. However, approaching Christmas, I felt my anxiety ramp up massively and this has continued. I am on low dose Sertraline. I have read that Mounjaro may hamper the efficacy of SSRI’s due to delayed gastric emptying. I am considering upping my dose but before I do that , I wonder if I let my Sertraline pill dissolve under my tongue, whether that would improve efficacy? In theory it would hit the bloodstream and bypass gastric route. But - would it damage the mouth / under the tongue ? It is not designed as a sublingual pill.

OP posts:
SilenceInside · 20/01/2025 14:53

I am not a HCP but I think you've answered your own question there. It's not designed to be dissolved in the mouth. I think that consulting whoever manages your sertraline prescription to ask their advice is definitely the sensible approach to this.

Lifeisblaaaaaaaaa · 20/01/2025 18:36

I am on week 11 tomorrow and 100% made my anxiety worse BUT I've dealt with it for so many years now I'm so far managing ok.

Would be good to klknow if there was some way to improve it tho. I did up my citalopram also which I think has just made my heart palpations worse.

susiedaisy1912 · 20/01/2025 18:46

If you need to stay on Mounjaro can you up your dose of sertraline?

Mounjaroscarednewbie · 20/01/2025 20:59

Yeah, just reluctant to do that as I think it may be partially responsible for the weight gain. But I probably will increase it . Plan to be on Mounjaro for a few more months.

Anyone else increased their SSRI dose successfully ( whilst on Mounjaro) ?

OP posts:
susiedaisy1912 · 21/01/2025 06:42

I'm on 150mg of sertraline and have been for years. I'm also on MJ and have lost a good amount of weight.

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