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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

HELP! Do I go back down to 2.5 from 5 due to bad side effects.

19 replies

HelloWorld2577 · 07/11/2024 15:06

Hello all

Firstly I was a bit silly and I technically took 5mg a week sooner than I should have. I did 3 doses of 2.5 and then when I took my fourth 2.5 I decided to see if I could get the golden dose out which I could and I injected that to start my first 5mg week. I had seen many others do this but completely understand it’s meant to be 4 x 2.5 first so please don’t shout at me for being stupid!

Injection day and the day after I was completely fine. But 2 days after jabbing I was violently ill, had diarrhoea and was nauseous and ended up being sick in the middle of the night. 3 days after jabbing I was still a bit rough but took Imodium and prayed for no more nausea and I’ve been okish since.

I am now approaching jab day and I was adamant when I was poorly I was going to take a break. But I’m now thinking do I move back to 2.5mg and then try 5mg in a few more weeks or just stick with 5mg as I’ve already started it and hope I don’t suffer again?!? Or do I do 3.75 so it’s a dash more than 2.5 but not as much?

I am really stuck and don’t know what to do! I am so scared of being sick again.

OP posts:
HelloWorld2577 · 07/11/2024 15:10

Just to add - the reason I went up to 5 is due to the 2.5mg not working as it did before. Food noise came back and it just generally wore off quite a bit. So I felt I was also ready for 5mg. But I’m just so scared to proceed with 5mg but also don’t want to backtrack at the same time! Stuck between and rock and a hard place! 2.5 I also only suffered with constipation nothing else it was fine. 5 I’ve had sulphur burps, diarrhoea, nausea, sickness & constipation. And I think sulphur burps alone would make me quit MJ as they are HORRIFIC especially when feeling nauseous 🤢

OP posts:
IMustBeInvisible · 07/11/2024 15:15

Personally, I'd go inbetween. I'd try 3.5mg or 3.75mg to bridge the gap and ease in just incase trying 5mg gives the same side effects again. Then slowly go up the doses as the body adjusts.

morbidcuriosity · 07/11/2024 16:01

Personally I would do a couple more 2.5 as its to get your body ready for 5..

Couple more weeks of 2.5 won't hurt and give you time to recover from feeling ill then try 5.
I never did the 3.75 people on here do. I did 5 weeks , 4 plus bonus of 2.5 then 5 and was fine.

ColaCar · 07/11/2024 16:07

I’d go back down to 2.5 for a week and then go to 3.75 for a week and then 5 again.

if I was ill on 2.5 then I’d keep at 2.5 for another week.

drippingtapp · 07/11/2024 16:09

Was 2.5 not working?

memememe · 07/11/2024 16:50

I've had similar, I did 2 weeks of 2.5 then did 2.5 plus half the bonus dose for week 3, then the same on week 4.

24 hours after week 4 dose I started with the explosive diarrhoea and felt so ill I couldn't eat at all, it's been 3 days now and I still feel so awful, I ordered the 5ml pen as I was intending to do 5 weeks of 3.75 but think I'm going to go back to 2.5 but inject every 5 days, yesterday I felt so I'll I was never taking it again! Sorry for the ramble!

twyst82 · 07/11/2024 16:53

I did the same as you and took 5mg a week early. Big mistake!
I was so ill for a few days. The second 5mg dose I was slightly ill but nothing like the first one.
After that I was fine as was fine moving up to 7.5 (this dose works well for me and I'm on my third 7.5 pen now)
I'd do 3.75 this week and if you're ok go back to 5 next week.

FlorenceB19 · 08/11/2024 19:31

twyst82 · 07/11/2024 16:53

I did the same as you and took 5mg a week early. Big mistake!
I was so ill for a few days. The second 5mg dose I was slightly ill but nothing like the first one.
After that I was fine as was fine moving up to 7.5 (this dose works well for me and I'm on my third 7.5 pen now)
I'd do 3.75 this week and if you're ok go back to 5 next week.

How do we access the 3.75mg?

5ft1
SW 12st 7lb
CW 12st 3lb
GW 9st 7lb

I've completed 2 weeks on 2.5mg.
W1d2 suppression kicked in, w1d3 intense suppression everything tasted too sweet to eat. Had Alpen for breakfast & felt like a tub of sugar had been poured over it!
W1d5 suppression eased up but no food noise.
W1 Lost 4lbs 🤗 W2 0 weight loss 😔

W2 I experienced comfortable general suppression, struggled to drink enough water, each day I ate bran flakes & banana for b/fast, ham sandwich/coleslaw on WM bread, pk of crisps for lunch, yogurt & blueberries for dinner. 4 black coffees & 750mls of water. I'm disappointed with no loss this week!

Due 3 jab tonight but then I need to consider ordering my next batch & unsure if I stay on 2.5 or increase to 5mg as the following day I'm due on holiday 11 nights in Egypt?

Do I increase dose to 5mg & risk possible side effects on holiday???

How do I manage jabs on holiday?
As pen needs to be kept in fridge & it's a 6 hour flight plus travelling time of 4+ hours?! Or do I wait until day 12 after holiday?

HelloWorld2577 · 10/11/2024 15:16

FlorenceB19 · 08/11/2024 19:31

How do we access the 3.75mg?

5ft1
SW 12st 7lb
CW 12st 3lb
GW 9st 7lb

I've completed 2 weeks on 2.5mg.
W1d2 suppression kicked in, w1d3 intense suppression everything tasted too sweet to eat. Had Alpen for breakfast & felt like a tub of sugar had been poured over it!
W1d5 suppression eased up but no food noise.
W1 Lost 4lbs 🤗 W2 0 weight loss 😔

W2 I experienced comfortable general suppression, struggled to drink enough water, each day I ate bran flakes & banana for b/fast, ham sandwich/coleslaw on WM bread, pk of crisps for lunch, yogurt & blueberries for dinner. 4 black coffees & 750mls of water. I'm disappointed with no loss this week!

Due 3 jab tonight but then I need to consider ordering my next batch & unsure if I stay on 2.5 or increase to 5mg as the following day I'm due on holiday 11 nights in Egypt?

Do I increase dose to 5mg & risk possible side effects on holiday???

How do I manage jabs on holiday?
As pen needs to be kept in fridge & it's a 6 hour flight plus travelling time of 4+ hours?! Or do I wait until day 12 after holiday?

3.75mg is 45 audible clicks of the 5mg pen.

Thats what I ended up going with last night so we will see if I have any poor side effects in the next couple of days 😬

The pen only needs to be refrigerated before you start to use it. Once opened can be stored at room temp. But if I was you to save the hassle I would jab the day you fly out with either 2.5 or 3.75 and then when you get home you’ll only be a few days late taking your second jab and that’s absolutely fine.

I would order the 5mg pen, but really wouldn’t take 5mg if you’re going on holiday as it’s highly likely you will experience side effects, seems as though most people do from 2.5 to 5. So order the 5mg pen and take a smaller dose from it either 30 clicks for 2.5 or 45 for 3.75.

OP posts:
FlorenceB19 · 11/11/2024 07:32

Thank you 🙏🏻

You have confirmed my thoughts with Really helpful suggestions 👌🏻
thank you 🙏🏻

How was the 3.75ms for you?

hopeishere · 11/11/2024 07:54

I'm actually due to move up today and was planning to go 3.75 first.

HelloWorld2577 · 11/11/2024 10:09

FlorenceB19 · 11/11/2024 07:32

Thank you 🙏🏻

You have confirmed my thoughts with Really helpful suggestions 👌🏻
thank you 🙏🏻

How was the 3.75ms for you?

It’s going well so far! Thank you for asking. No side effects like last week at all. Really happy with staying on 3.75mg for at least a few weeks before going back up to 5. I really want to lose weight with the support of MJ but I do not want to be physically sick or scared of eating because of side effects and with the 5mg last week I was so scared to eat! I was miserable. So I’m going to slowly move up! I weighed in today and I lost another 4.6lbs! Obviously due to being sick etc so not healthily done but I am hoping to get off a couple a week now whilst eating my calories! I’m taking vitamin d & biotin also as I’m worried the drop in cals will cause hair loss and I would rather not go bald 😅

OP posts:
Pegsmum · 11/11/2024 11:26

@HelloWorld2577 I’m in a pretty similar situation although I didn’t do the 5mg early. I had 5 weeks of 2.5 (with the bonus) and did consider slowly increasing to 3.75 before I went for the 5.
2.5 had stopped working and in my wisdom I decided to stick to the recommended dosage and just went for 5mg. Coming towards the end of a rotten week on it, awful nausea and up most of last night with diarrhoea so am going to titrate down to 3.75 and see what happens. Your experience so far of 3.75 has encouraged me to give it a whirl!

HelloWorld2577 · 11/11/2024 12:16

Pegsmum · 11/11/2024 11:26

@HelloWorld2577 I’m in a pretty similar situation although I didn’t do the 5mg early. I had 5 weeks of 2.5 (with the bonus) and did consider slowly increasing to 3.75 before I went for the 5.
2.5 had stopped working and in my wisdom I decided to stick to the recommended dosage and just went for 5mg. Coming towards the end of a rotten week on it, awful nausea and up most of last night with diarrhoea so am going to titrate down to 3.75 and see what happens. Your experience so far of 3.75 has encouraged me to give it a whirl!

Yeah I definitely would recommend the 3.75. It’s 45 clicks. I am thinking of doing a few extra clicks a week to slowly move back up to 5. So I’ve worked out if I do 50 it’s 4.16mg then 55 is 4.57 and then 60 is 5mg so may slowly move up until at 5 rather than going from 3.75 to 5 when I’m ready! Just want to lower the risk of feeling like crap again!

OP posts:
FlorenceB19 · 12/11/2024 12:27

Pegsmum · 11/11/2024 11:26

@HelloWorld2577 I’m in a pretty similar situation although I didn’t do the 5mg early. I had 5 weeks of 2.5 (with the bonus) and did consider slowly increasing to 3.75 before I went for the 5.
2.5 had stopped working and in my wisdom I decided to stick to the recommended dosage and just went for 5mg. Coming towards the end of a rotten week on it, awful nausea and up most of last night with diarrhoea so am going to titrate down to 3.75 and see what happens. Your experience so far of 3.75 has encouraged me to give it a whirl!

Aww.... I'm gutted that you ended up feeling so rough. Poor you! 🫶🏼

From various forums it's appears the slow increase tends to minimise the side effects. I think I will do the same to avoid a knock on effect while on holiday!
I hope the symptoms improve over time & that you're settled while increasing to the 5mg! 🙏🏻🤞🏼🙏🏻
Congratulations on the progress made so far & wishing you all the best for reaching your targets 🫶🏼

Please keep us updated 🫶🏼

Orangesandlemons77 · 12/11/2024 19:06

I'm splitting the 5mg dose in two and taking it every 3 days, this is working for me.

Orangesandlemons77 · 12/11/2024 19:06

2.5mg every 3 days I mean.

Maarva · 13/11/2024 15:11

Orangesandlemons77 · 12/11/2024 19:06

I'm splitting the 5mg dose in two and taking it every 3 days, this is working for me.

That’s a good idea. Does the pen work for 8 goes? Do you have to do a hard twist after the 4th one?

Orangesandlemons77 · 13/11/2024 16:07

Maarva · 13/11/2024 15:11

That’s a good idea. Does the pen work for 8 goes? Do you have to do a hard twist after the 4th one?

I've come across someone on a diabetes forum saying they have been advised to split the dose like this when they couldn't tolerate the 5mg.

I use insulin needles so don't need to do the hard twist thing, yes it would work with 8 needles. you can buy the insulin needles and normal needles online along with wipes.

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