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Mood swings - change from sequential to continuous

4 replies

16usernamechangesin16years · 09/10/2026 14:56

Just wondering if anyone else has experienced low mode and anxiety when switching from sequential to continuous HRT? I changed from Femoston 2/10, to Femoston-conti 1/5 plus an additional 1 mg estradiol tablet, so over the course of the month I'm getting exactly the same amounts of oestrogen and progesterone, but for the last few weeks I've had very low moods and been very tearful in a way that fails very hormonal. It's six weeks since I changed over.

I feel like it shouldn't be affecting me this much, since technically the doses are very similar, it's just that the progesterone is spread out over the course of the month.

OP posts:
LilyMumsnet · 09/10/2026 18:51

Just bumping this one for you, OP. Hoping some good support comes along soon. Flowers

JinglingSpringbells · 09/10/2026 20:35

I changed from Femoston 2/10, to Femoston-conti 1/5 plus an additional 1 mg estradiol tablet,

https://www.menopausematters.co.uk/perimeno.php
FEMOSTON 2/10*
Estradiol 2mg
Dydrogesterone 10mg for 14 days/28

https://www.menopausematters.co.uk/postmeno.php
FEMOSTON CONTI*
1 mg estradiol & 5mg dydrogesterone daily

Some women don't get on with daily progesterone (including me.)
I've stuck with sequential.

16usernamechangesin16years · 09/10/2026 21:48

Thanks for your reply, will take a look at those links

OP posts:
JinglingSpringbells · 10/10/2026 07:40

Hi There's nothing on the links other than the ingredients of Femoston.

Maybe it' s just you're not getting on with daily progesterone. That's not uncommon. You don't have to switch to continuous. GPs tend to follow guidance, but it's guidance, not mandatory. There are specialists who are fine with women carrying on with sequential.

You might eventually want to think about a different type of hrt. Dydrogesterone is very similar to micronised progesterone but some women do prefer one over the other.

Depending on your age and how long you want to stay on hrt, you'll have to come off tablet form at 60 and change to transdermal estrogen- patch, gel or spray. You can use dydrogesterone or micronised progesterone alongside as tablets (it's just oral estrogen that has a clotting risk.)

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