Anyone else had 4 failed transfers?

[Deedeebob]

i have had 5 ivf cycles now as follows:
1st - 8cell transferred- bfn
2nd- no transfer
3rd- 3bc 5 day blast transferred- early loss
4th- 4aa 5 day blast transferred- early loss
5th- 5ab 5 day blast transferred- bfn

I have a 5 day 3ab and a 6 day 4ab in the freezer but highly doubt they will work either.

Any stories of hope out there? Xx

Hi! I'm sorry to hear that. I haven't but will attempt a first transfer early next year so who knows what is awaiting us but it made me think of a thread mainly about two ladies following them live during multiple transfers, I want to say they had at least 3 if not 4 failed transfers and then they both got pregnant, one of them with twins ❤️
https://www.mumsnet.com/talk/infertility/5214667-due-to-start-stims-any-day-now-anyone-else?utm_campaign=thread&utm_medium=share

Wishing you all the luck in the world! No reason they won't work just because the others haven't!!!

Thank you so much ❤️

Following as I need this hope too 🤞🏻

I'm due transfer number 3 in the next couple of weeks, I went for my monitoring scan this morning and my lining wasn't quick thick enough so I think my transfer will be pushed back a week to maybe the 17th! My first 2 transfers both ended in early loss. I'm really sorry to hear about your 4, it must be really tough, I know I've lost any bit of excitement I've had about transfers in the past and just now have full anxiety. The only thing I've changed for this transfer is I requested low dose asprin, no idea if it will help but my clinic said there will be no harm in taking it so hopefully have a better outcome x

I've had 4 failed transfers after 2 cycles:
May 2023 single fresh transfer, failed/bled before test day
August 2023 double embryo FET, chemical
May 2025 single fresh transfer, failed/bled before test day
August 2025 single FET, BFN

I totally get where you're coming from with the lack of hope going forward. My brain is totally on the 'why the hell would it work this time?' train. We can afford one more round and then I think we'll have to call it a day.

What's your support network like? Have you had any counselling? Sorry I don't have a positive story to share but just wanted you to know you're not on your own. And I wish you all the best with whatever you choose to do going forward. Big unMumsnetty hugs to you

@WildForTheNight it’s soo sooo cruel isn’t it. I honestly feel really lonely. It feels like all my friends are moving on with their lives in a way I can’t relate to 💔 I’ve tried counselling but it hasn’t really helped xxx

How old are you? The reason I’m asking is that if you are older and the embryos haven’t been tested then it could just unfortunately be a numbers game - you might not have transferred a euploid embryo yet (as I don’t think embryo grade has any effect on that).

But if you are younger (and so likely making more euploid embryos) then my clinic said after 3 failed transfers then they would consider tests to check the uterine environment. Has your clinic mentioned any tests they might consider useful? Like Emma/Alice or NK cells? Or perhaps trying steroids or aspirin beforehand or checking your progesterone after transfer? Good luck, I’m sorry for your struggle

I’m 37. This has been going on for the last 3 years :(

I feel your pain and can relate. I’m pushing myself continue but cannot see this ever working.

1st cycle - total failed fertilisation.
2nd cycle - total failed fertilisation.
3rd cycle - transferred a day 5 4AB (missed miscarriage at 10wks, baby was 7)

just waiting for plan on how I go about doing a frozen transfer with my remaining 4AC and 4AB

Cant help feel they’ll be no good either

I’m so sorry ❤️ it is soo sooo emotionally exhausting. It’s actually cruel.
are you thinking a double transfer? I’m going to see if they will transfer my last 2. I honestly don’t think I have it in me to experience another 2 miscarriages. I mean I don’t actually have it in me to face another 2 💔

I want them both back in. I can’t do this anymore

❤️❤️❤️ same. I’ve been so down all weekend. Just so utterly fed up with it all xx

@Deedeebob so sorry to hear about your failed transfers, IVF is a cruel process, we have had 6 failed transfers all grade 5AA and 6AAs double transfers apart from the first one 4 early losses and 2 nothing implanted at all, I have had every test done and found nothing wrong, we are MF I really feel it's to do with the sperm, but they just don't seem to test this as much, he has had the normal tests done and they showed morphology and all that stuff but they tell me they choose 'good' ones for ICSI. I am also exhausted with this process, it's mentally and financially draining I bet in total we are close to 50k and still no baby.
Sorry no positive news at this end all we can do is keep going

Hi ladies, I’ve just come across this thread after my 4th failed FET 😞💔 Just wondering how you all got on with any subsequent transfers since this thread last year? Really hoping there are some positive stories 🙏 🤞 but I also know this is a cruel world and Mother Nature is not always kind to everyone. Would be good to hear from any of you @Deedeebob @Alexandrine @camelinastorm @PlanBFertility

Hey lovely. My final transfer worked and I have a 3 day old little boy.
I'm so sorry that you are going through this. Do you have embryos left? I was on my 5th ivf cycle xx

Congratulations @Deedeebob 🌈🩵 It’s so good to hear success stories. No more embryos and were definite this would be the last but now it’s a BFN we’re thinking of trying one more round in a different clinic! Did you transfer your 5 day or your 6 day embryo? Did your protocol change? What and how much were you taking? I don’t think I’m getting enough progesterone. Just a gut feeling. I’ve always just been on 2 pessaries a day from 4 days before transfer up to beta test, and my level is always around 40 nmol before transfer and fluctuates in TWW but never above 53 nmol. I think it should be higher 🤔 Any advice much appreciated xx

I transferred them all. It was the day 6 blast that worked. What clinic you with?
I researched quad therapy. It's basically clexane, progesterone injections, steroids and aspirin. I also did a medicated transfer, so HRT. You know your own body so tell them you want the PIO, it causes no harm :)
id put in a contingency plan in that I was going for donor eggs if the last cycle hadn't of worked, and I think it helped me mentally.

on our last round we used highest dose stims, icis, aoa and zymot. I pretty much told the doctor that I wanted all those things - they didn't suggest any of it xxx

@VioletHaze24 I’m so sorry you are going through such a difficult time. I just wanted to add that we had success on embryo number 6. I think similarly to how some people get lucky on the first transfer, others get the bad luck hand of cards. Regarding progesterone, trust your instinct. My clinic (CRGH) insisted it be over 100. Clinics differ but if you think it should be higher maybe change clinic to see if their approach works better for you. It’s such a difficult journey, be kind to yourself x

@VioletHaze24 aieey to hear of your failed transfers ours literally worked this year on about our 8th double and some triple transfers it was a long awful slog, the horrible thing is I fully disconnected from my pregnancy and even the birth, I think it was due to all the negatives I had and I just couldn’t enjoy it, would recommend to anyone after such a large amount of failed transfers to get support when you do get that positive

Thanks for replying @lemons44 and @camelinastorm Congrats to both of you for persevering and achieving your positives. It really is a long, difficult journey. Sometimes I just sit and wonder how the hell we ended up here. Very frustrating. If we do one last round then I’m going to really push for extra progesterone. So how much did you take @lemons44 to get your level over 100 nmols? Was it 2 or 3 pessaries a day plus a Lubion or 2 injection a day? Seems a lot 😨 but if it works then great!