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Starting sertraline tomorrow, how long before you noticed any improvement?

7 replies

Sleepy21 · 21/08/2026 10:04

Due to start sertraline tomorrow - looking for others experiences and how long before I feel an improvement? Even if it’s only mild Thank you!!

OP posts:
Sleepy21 · 21/08/2026 10:06

Forgot to add as well, when is it best to take it? Morning or evening?

OP posts:
NelferchyLlyn · 24/08/2026 23:12

Hi, for me I started to slowly feel better after 3 weeks.

I took a couple of weeks off work, slept lots.

I take mine in the evening but its different for everyone. Its really helped me, good luck!

SaulHudsonDavidJones · 24/08/2026 23:52

It took me about 2 weeks to adjust then I started to feel better. At some point soon after I felt a million times better and have continued like this for about 3 years. It truly has been life changing. I feel ‘normal’.

Sleepy21 · 25/08/2026 15:59

Thank you all for more positive stories! It’s keeping me going - I’m having a few bad side effects and my anxiety is coming and going in waves but I’m pushing through it as I know it will soon help 🤞I just keep thinking about feeling better!

OP posts:
Prycejosh1987 · 25/08/2026 23:50

Different drugs work differently for different people.

AmberSpy · 25/08/2026 23:52

Probably three weeks and unfortunately it did take my stomach a while to adjust. But now, like others in this thread, I can safely say it's been a real game changer for me. Made my life so much better. I hope it works for you too!

Tarkan · 25/08/2026 23:55

I’ve been on it for 3 weeks now and definitely have an improvement. It’s not perfect but it’s better. Morning actually works best for me to take it, I tried both as my DC was better in the evening with it. I might be getting an increase in dose after another 4 weeks depending on how I’m doing as my doctor said it can take up to 6 weeks to fully see a difference.

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