Random notes and thoughts from a non-scientist:
Is debating 'male / female brains' really a pointless dead end?
It seems to me that throwing hands up and saying 'oh it's because male brain, female body so the only thing to do is cut and drug' would be a gross dereliction of our duty of care as a society.
It seems to be more down to software than hardware.
Hardware (brain) as in a physical construct developed via DNA for sex, nutrition for building and experience for physical shaping.
Software (mind) as in a complex response to every experience and observation a child is exposed to.
Many trans and detransitioned people have written that they've realised personal trauma was at the root of their experiences.
Counselling, talking therapy, listening, sharing positive role models and examples etc could have helped them come to terms with reality - but of course this then leads to cries of 'conversion therapy!!!!!' which has been labelled A Bad Thing.
I don't know.
I'd welcome Mumsnet's scientists' response.