Books to get lost in for a burnt-out brain

[natura]

I'm post-breakup, post-international move, physically exhausted, flooded with cortisol, perimenopausal, and both my heart and my brain feel utterly broken.

I want to get lost in a story that's engaging but not too demanding, easy but not vacuous...

Think Ann Patchett, Donna Tartt, Jodi Picoult, that kind of thing.

Anyone got any good suggestions?

My go-to comfort read is always the Discworld series. Always lifts my spirits

Not the genre you asked for, but The Penguin Lessons would be perfect for your current headspace. It's absolutely delightful without being twee.
Hope you are feeling better soon.