I never seem to have what I need in mine (usually tissues and lip balm!) so I've just been through and sorted it out! I now have..
purse
phone
keys
memory stick for work
lip balm, eyeliner, handcream
tissues
spare knickers (for DD2-not me!)
pencils, pen+pad of paper for bored children
small thing of sunblock
safety pin, ibuprofen and plasters.
What else should 'grown-ups' have in their bags!!?