I have lived in chorlton, didsbury, glossop, and saddleworth.
I think it depends on your age, in my twenties didsbury was amazing, lots of bars, easy access to the city. Chorlton was very similar.
What I would say about didsbury is schools..its a nightmare unless you live on beAver road.( It was church admission I think when I lived there.) in all honesty I moved because I wanted to buy, I think whilst it's a cool place to live when you are in the pub all the time, there are better places when you have children.
Glossop is lovely and has good access to trains and the peaks. No idea about schools.
Saddleworth, Dob cross and the surrounding areas are a great mix of country, lots of playgroups and some good schools. Good train, access to motorway. Good access to walks etc.
Sale, timperly, altrinham never floated my boat, I found sale scruffy, I worked in timperly for a few years and it was boring. ( sorry to any residents, plus it may have changed) it is just a mass of suburbs.
What are you looking for, do you have any hobbies? What do you do at weekend now?