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Estriol 1% cream causing symptoms?

4 replies

CardiffCate · 07/11/2026 06:38

I have been taking this for 9 weeks and in the last 2 weeks have had sore boobs and slight bleeding. I only take it every 5 or so days. Could it be causing this? I cant take estrogen through HRT. Has anyone else had this and will it settle down?

OP posts:
NapsForTheWin · 07/11/2026 06:57

I have used Ovestin and find, for the first little while, it did cause sore breasts. It settled down after about two weeks. No bleeding though. I think you are supposed to use it twice a week? Maybe with spreading it out further your body isn't having a chance to adjust? I do find if I take a break and start again I'm back to sore breasts.

JinglingSpringbells · 07/11/2026 07:24

Probably not the cream. By the way is it 1% or 0.1%?
The small white tube with purple writing is 0.1%.

If you used it 100 times (2 times a week for a year) the dose of estrogen is the same as one day on HRT- it's that weak.

It's only absorbed in the vagina which is why it can be used by (most) women who have had breast cancer.

If you are not post menopausal yet and still have periods, the symptoms are perhaps your own irregular cycle?
You can get slight bleeding - this is on the leaflet in the pack- but if you are post menopausal you should see your GP.

Is there a typo in your post- you said you 'can' take HRT.

CardiffCate · 07/11/2026 07:56

Yes, sorry, I can't take HRT because of breast cancer. I m very sensitive to estrogen but thought it shouldn't have this effect. Maybe I'm not taking it enough, as said above.

OP posts:
NapsForTheWin · 07/11/2026 07:57

CardiffCate · 07/11/2026 07:56

Yes, sorry, I can't take HRT because of breast cancer. I m very sensitive to estrogen but thought it shouldn't have this effect. Maybe I'm not taking it enough, as said above.

Have you followed up with your doctor?

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