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Alteration in bleeding directly after switching to Gepretix progesterone from Utrogestan?

1 reply

Kedwic · 01/11/2026 15:18

After switching to gepretix progesterone from Utrogestan this past month I have had a bit of a different bleed. I used the gepretix vaginally exactly as I would use the utrogestan and after stopping had a normal bleed with a bit more clotting and usual. Then it stopped and day or two later started again for a day or so. Then a week later I'm bleeding again but old dark blood with a few clots.

Apparently changes in bleeding are normal within 3 months of changing your HRT in anyway and that I should just leave it to settle down for the next few months.

Has anyone else had this on switching from Utrogestan to Gepretix? Did it settle down once you got used to it?

I am peri so may still have an underlying cycle but have been on HRT for a few years now.

OP posts:
Perimenostage · 03/11/2026 11:07

Gepretix and Utrogestan are both 100mg micronised progesterone, so on paper the switch shouldn't change much, and I haven't seen anything showing the generic behaves differently when used vaginally. One thing worth knowing is that in the UK both are licensed to be swallowed when they're used for HRT, so vaginal use is something your prescriber agrees to off licence. If whoever prescribes it doesn't already know you use it that way, tell them.

On the bleeding, NICE guideline NG23 says unscheduled bleeding is common in the first 3 months of HRT and should be reported at the 3 month review, or promptly if it happens after that. You've been on HRT for a few years with a settled pattern, so an extra bleed a week after your usual one, with old blood and clots, is worth telling your GP about now rather than waiting to see if it settles. A note of the dates you start and stop the progesterone and the days you bleed will make that appointment much quicker.

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