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Switching from Utrogestan to Gepretix - My Experience

1 reply

Spiggot · 20/08/2026 11:56

I just wanted to share my recent experience after I was switched to Gepretix from Utrogestan by my GP. I know we are told they are technically the same medication, just a generic brand alternative but I’ve just had the worst month of my life and wondered if I’m the only person who experienced this!

It had taken me over a year to get my dosage and combination of gel/capsules right and at the start of summer there I was feeling like it had finally slipped into place. The switch came with the assurances it was the exact same thing as Utrogestan and I shouldn’t notice any difference but within a few days I started to feel off.

Fast forward to one month later and I had period cramps, sore boobs (not had either of those in years), dizzy spells and visual migraines (zig zag auras). The brain fog came back with a vengance and I really had to concentrate on finding the words I needed. Night sweats and irritability came back too and I had no energy or enthusiasm for anything.

I really tried to ride it out in the hope it would settle down but my mood plummeted so low that I was starting to have suicidal thoughts. One panicked emotional call to my GP later and she put me back on Utrogestan (as well as a host of bloods to test for other things). Within a couple of days my mood has lifted and I can start to feel all the other symptoms ebbing too!

The only thing that changed was the switch from Utrogestan to Gepretix and it was such a drastic difference for me, that I am absolutely certain they are not identical. While the active ingredient may well be technically the same, whatever small differences there are in the manufacturing process or non-active ingredients they are most definitely not the same.

I’d just honestly love to know if anyone else has had a similar experience or if my body is just a bit of a drama queen!

OP posts:
Additup · 20/08/2026 12:54

I had a similar experience but with the Accord brand of micronised progesterone.

I've taken utrogestan, dr reddys and zentiva brands which havd all been fine. Accord brand gives me a constant migraine. I've tried it 3 times now for about 5 days each time just to make sure.

It has exactly yhe same ingredients as dr reddy but apparently drugs can still release the active ingredient differently even if they contain the same thing.

It's on my pharmacy notes now not to prescribe it to me.

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