Constant Adrenalin fight or flight

[FA07]

Hi everyone,
I'm new here and wanted to reach out as I personally don't know anyone who has experienced the same symptoms as me. I'm hoping to connect with anyone who has experienced something similar or is on a similar path.
Through my test results, I found out that my perimenopause has triggered a bit of a domino effect: flatlined cortisol, insulin resistance, Hashimoto's/ thyroid dysfunction, and worst of all—constant, wild adrenaline surges and intense internal vibrations/ buzzing.
I tried taking estrogen, but it made the adrenaline and internal jitters so much worse that I had to stop after just 4 days. My system just could not handle it.
Because of this, I've started taking Utrogestan 200mg micronised progesterone on its own without estrogen to try to calm down my nervous system and stop the constant adrenaline loops. I started it just over a week ago.
Has anyone else dealt with this specific combo of symptoms...flatlined cortisol, insulin resistance, thyroid issues, high adrenaline, internal vibrations?
How did your body handle taking Utrogestan alone, and did it eventually help calm the adrenaline down?
I'd love to hear your experiences—it would mean so much to know I'm not alone in this! Appreciate any feedback.

Through my test results, I found out that my perimenopause has triggered a bit of a domino effect: flatlined cortisol, insulin resistance, Hashimoto's/ thyroid dysfunction, and worst of all—constant, wild adrenaline surges and intense internal vibrations/ buzzing.

Sounds awful.

Do you mean peri has given you low cortisol, diabetes, Hashimotos etc and thyroid issues? Or were they only diagnosed as the result of a full blood test for peri?

What dose of estrogen did you use? It's best to start very low and work upwards.
Many GPs don't do this.
My consultant advised 1/2 pump of gel for a few weeks working upwards, as necessary.

Micronised progesterone on its own won't do anything except act as a kind of sedative.

It's best if you see your GP again and ask to be referred to a specialist - maybe there is a local menopause clinic for more complex cases?

yes the peri has brought all of this on. I didn’t have it before. I can’t have estrogen because my estrogen is quite high so adding more only adds to the Adrenalin surges. Iv been taking utrogestan progesterone for just over a week, it doesn’t really sedate me much but I’m going to keep going to see if it helps calm the Adrenalin surges.

Is this in the UK?

The 'estrogen is too high for HRT' doesn't make sense- you've been prescribed it. It's a bit confusing.

Sorry but I don't understand the timeline of tests and diagnoses. You need referring to an endocrinologist (unless you are already seeing one.)

Can I ask where the evidence came from that peri brought all of those other diseases on?

How has your cortisol flatlined? You need cortisol to keep everything running; if you’ve developed Addison’s disease I imagine you’re under a consultant?

Is your thyroid issue being treated with thyroxine?

I have had lots of issues in peri with hypothyroidism. Half of it was stress and half of it was the fluctuating hormones.