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Slynd - Please share your experiences of using Slynd (progesterone) as part of your HRT regime.

18 replies

1990sMum · 28/03/2026 16:42

I'm about to start Slynd after really struggling with Utrogestan for years.

I'm scared.
I'm so depressed from using Utrogestan that I am worried about my mental health deteriorating further, if I react to the Slynd.

This is has gone on for nearly 9 years so I'm really hoping this form of progesterone works for me.

All advice and experiences appreciated.

OP posts:
Uberaddict · 28/03/2026 16:55

I was on the hysterectomy pathway for heavy bleeding and consultant suggested Slynd plus oestrogen gel pump. I had 60 days of break through bleeding and then one day it just stopped. I take it back to back - no other issues. Tbh it’s been life changing for me

1990sMum · 28/03/2026 16:58

Thank you. I could cope with bleeding. Its my mental health I'm scared about.
My consultant recommended a hysterectomy but its not for me.

OP posts:
namechangeabc123 · 28/03/2026 17:55

Have you tried using the Utrogestan vaginally instead of taking it orally?

1990sMum · 28/03/2026 19:32

namechangeabc123 · 28/03/2026 17:55

Have you tried using the Utrogestan vaginally instead of taking it orally?

Yes, sadly I still struggle with the side effects.

OP posts:
Cbpoppy · 17/04/2026 15:59

Hi lovely

Just seeing how you got on with Slynd?
Do you suffer bad with anxiety?

1990sMum · 17/04/2026 22:08

Cbpoppy · 17/04/2026 15:59

Hi lovely

Just seeing how you got on with Slynd?
Do you suffer bad with anxiety?

So I'm on week 3 and its literally been life changing.
This is the best I've felt in over 10 years. I feel like my brain is waking up.
Its incredibly difficult to articulate but I feel so much better.

Since going into premature menopause I developed terrible anxiety. Utrogestan, Femoston and combi patches made it so much worse.

I was on depo Provera and Provera in my 20s, I thought I had a nervous breakdown but now I realise it was the progesterone.

OP posts:
Uberaddict · 17/04/2026 22:10

Yay! Really happy for you

Cbpoppy · 18/04/2026 08:32

Oh wow thats great. I'm early peri I believe and anxiety with panic attacks and spikes at different times. Estrogen made me feel worse. Really interested to try slynd as wander if this might suppress ovulation and period which would be amazing

tomoveor · 21/10/2026 13:19

Hi just wanted to see how you are getting on now with Slynd? Am just starting and v nervous

1990sMum · 21/10/2026 23:10

I'm still on it.
I have had alot of spotting but my mental health is so much better.

Ultimately, its worth trying. You can always stop if you don't get on with it.

OP posts:
HeBeaverandSheBeaver · 22/10/2026 00:00

Is that the bio identical progesterone

ThreeMogsAndCounting · 22/10/2026 00:39

HeBeaverandSheBeaver · 22/10/2026 00:00

Is that the bio identical progesterone

No. Slynd is synthetic. And they have different effects on different peiple

Im actually on slynd and utrogestan, because the bio identical progesterone is amazing for my mental health, but the slynd has stopped my periods, which means the pmt mental health dips are suppressed too. I did come off the utrogestan for a bit when I started slynd and it didn't take long for my mood to start deteriorating again.

But as the OP says, the awesome thing about hrt is you can just come off something if it doesn't work. Unlike anti depressants which can have horrific side effects.

Im so pleased to hear you're so improved OP. When HRT works its fucking transformative

1990sMum · 23/10/2026 19:35

I wouldn't go so far as describing HRT as transformative.
Unfortunately the bleeding has really increased (7 months in) so I'm thinking of stopping HRT as slynd literally was my last resort.

OP posts:
LethargeMarg · 23/10/2026 19:58

im on jt and haven’t had a period since starting. my mood is much improved but sex drive has nose dived. sleep isn’t great and i think ive put on weight around my middle (last winters trousers are v tight). also wasn’t told to avoid 4 day break when combining with estrogel until i read that on here

ThreeMogsAndCounting · 23/10/2026 23:59

LethargeMarg · 23/10/2026 19:58

im on jt and haven’t had a period since starting. my mood is much improved but sex drive has nose dived. sleep isn’t great and i think ive put on weight around my middle (last winters trousers are v tight). also wasn’t told to avoid 4 day break when combining with estrogel until i read that on here

Oh that's a good point. GPmtold me to throw the green pills away.

And im sorry it hasn't been transformative for you, OP. Im a bit evangelical because I went from suicidal and non functional to better than my old self within six months, but it's such a process with a lot of nuances and tweaks.

1990sMum · 24/10/2026 14:26

ThreeMogsAndCounting · 23/10/2026 23:59

Oh that's a good point. GPmtold me to throw the green pills away.

And im sorry it hasn't been transformative for you, OP. Im a bit evangelical because I went from suicidal and non functional to better than my old self within six months, but it's such a process with a lot of nuances and tweaks.

I definitely felt better on Slynd. I knew if I carried on taking Utrogestan, I would eventually kill myself or someone else.

Ive been spotting/bleeding since June so its not working for me.

I hate having to take HRT. It caused as many issues as it resolved.

OP posts:
tfu · 24/10/2026 22:40

I had a terrible experience on Slynd I’m pleased it’s helping you OP

NothingMakesSenseAnymore · 07/11/2026 23:40

1990sMum · 24/10/2026 14:26

I definitely felt better on Slynd. I knew if I carried on taking Utrogestan, I would eventually kill myself or someone else.

Ive been spotting/bleeding since June so its not working for me.

I hate having to take HRT. It caused as many issues as it resolved.

So sorry to hear its not going well. Im exactly the same as you and gave up utrogestan and oestrogen as I too was in the depths of depression. Slynda gave me my brain and a hint of joy back. Im nearing end of 2nd pack and getting worried as my anxiety and mood is dipping slightly again.
Do you mind me asking did you take back to back packs and skip the green pills and did you feel the positive effect decreasing as you went from month to month.
Im so sorry if you have to stop it. Its last option for me too as adding hormones messed with me mentally.

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