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Menopause

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When to take progesterone in sequential HRT cycle?

4 replies

Trigons · 06/02/2026 10:59

I have started HRT in sequential cycle. 2 pumps gel and 200 mg prog. My dr advised starting prog with estrogel on day 1 of cycle. its now day 9 and most of the day I have felt really spaced out. I did some research and saw that the advise is to take progesterone on day 15 of cycle so have I been taking it when I shouldn't? I also read somewhere some drs have prescribed for day 1. How does it affect periods?

OP posts:
kingcake · 07/02/2026 19:29

I don't think it matters when you start it, you will most likely end up having a bleed after you finish the 12 days of progesterone. I asked Chat GPT to make me a schedule and it recommended that I take it on the 15th to the 26th of every month, just to make it easy to remember, rather than count days of a cycle.

Awrite · 07/02/2026 19:31

Yeah, I take it the 1st to the 12th of the month to make it easy to remember.

namechange0998776554799000 · 07/02/2026 19:37

The GP told me to just take it from the 1st to the 14th of the month. As it happened that was completely out of sync with my cycle so I ended up with periods every 2 weeks for about a year (light withdrawal bleeds around the 15th of every month, actual periods around the beginning of every month). I switched to patches (not for that reason) and they eventually settled down to once a month.

Choosing calendar days is definitely the easiest with the gel, otherwise it's easy to lose track and take too much/too little.

The progesterone tablets made me very spaced out, I do better on the patches. But you need to give it a few months to see if you get used to it or need to try something else

Awrite · 07/02/2026 19:40

Also, I take it with food about an hour before bed and sleep like a log. I heard an expert on a podcast suggest this and it works like a charm.

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