I've recently noticed that my wrists feel a bit weak when I do something like lift a jug of water. My thumb joints also weirdly don't seem as strong as they were and a couple of times I've bent them back wrestling a very tight pillowcase onto a pillow (very painful..I don't recommend). I'm 51 and have been on HRT for a few months. Anyone else experienced that sort of thing? I've never had joint problems and always been quite sturdy.