I am currently using Evorel 100 patches and have no problems with them apart from they quite often partially come off during exercise, but then will stick back on after I've had a shower and got dried. I don't know if some of the active ingredient gets washed off in the shower. They are properly stuck on to begin with and I don't think it is clothing seams rubbing, it seems to be just from getting sweaty. I do put a new one on occasionally but it doesn't seem right to be replacing them three or four times a week.
I have read that Estradot patches are a bit smaller and stick on better but wondered if they would have any side effects if I changed.