Please can anyone help me, I was on 2mg oral hrt for 11 yrs and now as I am over 56yrs I firstly changed to 50gm patch but felt bad on it so changed to Sandrena gel 1mg 3 weeks ago and ever since I have had the worst nausea ever and my IBS is really awful, also I feel miserable, how long shall I give it before I give up.