I’ve been on estradot 50 (plus progesterone on days 14-28) for approximately 5 months and was definitely feeling better. However, over the past couple of weeks I’ve been experiencing irrational anxiety and awful nighttime waking with anxiety and hot flushes. I’m also feeling general rage again. These were my original main peri symptoms and the reason I sought hrt. Do you think I need to up my oestrogen dose? Is 75 very high? I’m 47 and still having periods.