Just that really, I increased Estradiol (sandrema) from 1mg to 2mg a few months ago - was told to do this by gynaecologist for bladder weakness thought it would also make mood better. But now piecing bits together before GP appt tomorrow which is about anxiety and depression and wondering if upping this may have made it worse? always thought it would make it better. I take progesterone for 12 days and usually feel worse during this bit of cycle. Wondering whether too change regime from 2mg sandrema and 12 days progesterone to a patch or something else. people mention a pump of gel a lot what brand is this ? mines in sachets? Is it worth getting an oestrogen test? just want to go armed to GP as scared they'll recommend antideprerssants