I am peri and take 2mg daily of Sandrema estradiol daily- initially started on 1 g 2 years ago but gynaecologist increased to 2 in the summer. I've found recently my anxiety and mood and brain fog are terrible, have online appt with GP next week and wanted to know if increasing the dose of this is possible and if it works for mood . anxiety etc.Looked online seems 1- 1.5g is normal dose so im already taking a lot. To be fair this may not be meno related as have had my fair share of stress and reasons to be depressed this year but would rather try increasing this than ADs or anxiety drugs. I exercise, eating well, CBT and vitamins and supplements galore but when im anxious I feel sick so don't eat enough or feel like exercising. At the end of my tether. Sometimes I feel ok but I feel not Ok too much. Maybe I should look at a change of brand?