I'm 52 and definitely peri.Only 2 periods this year and having loads of symptoms but no hot flushes. Six months ago I had a uti but after antibiotics still had symptoms second sample was negative so no bacteria. Thought I must be imagining symptoms no pain but constantly had a feeling I needed to go.Sometimes stinging other times just an irritation "down there"No continence issues no desperate urgency just this annoying feeling.Eventually it seemed to go and I got on with life.Now it has returned.Urine sample was clear but for the last 6 weeks it's taken over my life.After some research wondered if low oestrogen was to blame.Saw a different dr at surgery today,he was lovely,he wasn't sure if this would be the case in peri thought it only happened in menopause as I still have some oestrogen.He agreed to me trying vagifem to see how I got on so have now picked up my prescription.Just wandered if anyone could tell me how long before I know if it's working.One thing I read said 12 weeks!! To be honest I'll be suicidal by then.Going back to dr's in a month to discuss this other hrt.Any help out there.