I'm near the end of the Perimenopause, I could be post menopause as I haven't had a period since February. In just two years I've developed osteoarthritis in my hands (and in knees, wrists, ankles etc - quite extensive). I had xrays two years ago and they showed no sign of destruction and deformities. Now one hand is displaying physical damages especially in my thumbs. I believe this all happened due to fluctuating hormones. Could HRT slow the progression of osteoporosis? My thyroid has also been destroyed. I am basically a wreck and cry every day. I'm 50.