I have been having hot flushes for 9 years now and have been on and off hrt of all types, pills, patches and gel for short periods. I have also been prescribed venlafaxine and clonidine all of which worked for very short periods. Now I am having the worst flushes ever and am at my wits end. I saw Serenity and am thinking of buying it, but there are mixed reviews on this forum. Anybody out there got any other suggestions?