Trialling manopour. Any info would be great

[Miraclemuma03]

Hi! I have just had my 4th failed ivf cycle for another child. Im 41 and in perimenopaus and amh 1. I dont make embryos to get to transfer and if I do get to do a transfer its usually with a very poor quality embryo. I said I wasnt going to do any more cycles as my clinic just kept using the same medication but increasing the dose which clearly isnt working so was giving up. My FS has asked me to try again trialling a different medication. I was previously on puregon but switching to manopour which my FS said is probably more suited to my age and she has had success with other patients my age. She also let me know that I might not respond at all and just to keep an open mind, so its a bit of a gamble. I guess before I actually commit to another cycle, im wondering how others my age with very low amh have gone using manopour or even just switching from one medication to another. Did it really make a difference and did you have a baby?

I only had two rounds on NHS which did not result in baby sadly. Both rounds I was given menopur. The first round, I started on 150 and went upto 225 but was aborted before egg retireval as showed very little progress. The second time around, I was started at higher dose 275, and on day 5 scan again, there wasn't much progress, the nurses still felt it was an under response based on my AMH measured at 26 they were hoping to see more follicles recruited but they increased it further to 275. Things looked better on day 8 scan. On egg retrieval think day 13, there were around 4 follicles that measured 16mm to 21mm. However, only two had eggs, and only one was mature, which didn't fertilize. So in my case, it wasn't a great response, but apparently it's a good drug that helps both growth and maturity of eggs.

My BMI was at 30, I believe this may have made a difference to my body absorbing and responding to the doses, because so many women on here had good response to menopur.

Hope this helps