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Infertility

Our Infertility Support forum is a space to connect with others in the same position, discuss causes, treatment and IVF, and share infertility stories of hope and success.

Progesterone pessaries

4 replies

GimmieABreakOr3 · 19/06/2026 17:46

Anyone else taking these? 2nd week for me although I’m taking them rectally. At first I was fine, apart from very very tired but now I’m feeling emotional, tearful and quite nauseous. Wondered what others experiences were?

OP posts:
Miraclemuma03 · 20/06/2026 01:11

Not currently on progesterone pessaries but maybe on day 3 I start getting bloated, hungry, sometimes headaches, cramping, back ache, spotting, mood swings, thirsty. All sorts of side effects sometimes even nausea.

PlanBFertility26 · 20/06/2026 15:45

I’m on pesseries and injections. They always make me feel rotten

26birdsong · Today 12:54

Been taking them alongside letrozole cycles for a while. I don’t think I’ve had massive side effects but then I do feel more wiped out - but not sure if that’s the letrozole, progesterone, or infertility burn out!

GimmieABreakOr3 · Today 14:24

26birdsong · Today 12:54

Been taking them alongside letrozole cycles for a while. I don’t think I’ve had massive side effects but then I do feel more wiped out - but not sure if that’s the letrozole, progesterone, or infertility burn out!

Sorry to hear you’re feeling a bit burnt out. I’m here for you if you ever need a chat, feel free to PM me.

I was surprised at how much they wiped me out. My first cycle of IUI looks like it’s failed so I’m glad to be having a bit of a break from the progesterone.

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