Any Tips for meriofert.

[H1ghH0pes]

I had a failed cycle last year which was due to egg quality. This cycle instead of Bemfola for the stims they have given me Meriofert as they believe it helps with egg quality.

I'm on 5 vials to 1 liquid but worried I'm not injecting enough... Is the amount of fluid supposed to decrease as you mix with the powder? I'm only injecting about 0.1 - 0.2 ml per day so far.

Also any tips on opening the solution without cutting my fingers. They showed me twice at the hospital as have been for 2 baselines so far and they made it look so easy.

Anyone else had any experiences or tips?

I was on 3 vials and then 5 and the liquid in the needle seemed to change every time! I don’t remember it ever being less than 0.5 though?? With the solution, they gave us ampoule snappers to snap the top off, did your clinic not give you any?? I was worried that the liquid was different each time so we just took it really slowly and tilted the vial to make sure we had got out as much as we
could! X

Thank you. No we didn't get anything to snap off. I will ask at my local chemist tomorrow to see if they can give me any ampoule snappers

I wish I could remember better. I had about three vials to one liquid so I had a lot of leftover liquid ampoules to practice with. There’s a knack to it and once you get it it’s easy.
I remember having to redo and redo it to get all the liquid in the syringe. If you tilt it and turn the syringe you can get every drop. Just make sure you aren’t in a hurry.

I think 5 to 1 sounds like too many doses for a single solvent - I did 4 and was told that was the max (indeed I think the packaging said max was actually 3!). It may be that you need to mix 3 with 1 solvent and 2 with another 1 solvent, which does mean two injections but do check with your clinic first.

I found it took a while to get into the swing of mixing the meds but then I found it quite therapeutic. I would put a chill out playlist on and play at being a pharmacist, I found taking it really slow helped.

You should have definitely been given some plastic ampoule snappers!!!!

The glass vials are easy once you know how (I was on meriofert and I'm a nurse). The trick is to snap away from the weak spot which is the little red dot (ive added a photo). Hold the top and snap away from the red dot, making sure all the liquid is out of the lid before hand. You can get it out of the lid by flicking it or rubbing the bottom of the vial on a surface. If you are still struggling then use a piece of tissue to hold the top. I have lots of the "safe snap" lids left over as I didn't use them because I'm used to glass vials. More than happy to post them to you if you want.
There shouldn't be any loss of fluid when you mix a powder to a water, the volume should actually increase due to displacement. For example a common antibiotic we use in work requires 5.6mls of water to give an overall concentration of 600mg in 6mls because the powder makes up the extra 0.4mls (much much larger powders than meriofert though so you shouldn't see such a huge increase). The thing I found with the meriofert was quite alot of the drug once mixed getting "stuck" around the top of the grey inner bung. To make sure I got every last drop, once I had drawn the majority of the fluid out with the vial upside down, I turned it back and gave it a flick so the remaining fluid was at the bottom of the vial and then inserted the needle to the very base.
All of this is very easy for me to say becuase I draw iv drugs up on a daily basis. I really get how hard this must be, I wouldnt let my husband mix any of the drugs up for fear of him loosing a little. I'm sure you are doing a fab job though.

Thanks so much guys and @Mseddy I have followed that process and have managed without ampule snappers. Got Day 10 of meriofert scan on Monday and fingers 🤞 crossed they will let me know when I can trigger and egg collection.

Got everything crossed for you 🤞🏼 glad you managed to snap the vial ok

Just about to start my first egg collection round for ivf after two miscarriages. Now aged 37. Very nervous. Reading through threads as I will be on Meriofert. I hope everyone is well and would love to hear how everyone is getting on? xx