TROPHY - hysteroscopy trial programme at Guys

[jumpingjackhash]

We're undergoing ICSI treatment at Guys (1st round last year resulted in bfp then mc early on, FET early this year was a neg result) and this morning our consultant suggested we consider taking part in a trial they're currently running called TROPHY.

Essentially (as I understand) it's to see if hysteroscopies can help with IVF/ICSI success rates. If we get selected for the hysteroscopy (vs being a 'control'), it could potentially be done quite quickly so we can begin treatment when my next cycle starts (Day 1 is within the next week or so).

Has anyone else heard about this? Anyone considering or currently involved and willing to share thoughts or experiences? I've never been involved in any medical trials before so want to find out as much as I can before making a decision either way. We met the consultant leading the trial (we've met him a few times, he's good and understanding!) and he's calling over the weekend to talk to us more.

I understand that signing-up means I might not actually get the hysteroscopy - if that's the case the consultant has suggested a SCS ('saline cavity scan') so we can take it from there. However I need to confirm if we're doing that on Day 1 of my next cycle, so we have the bank holiday weekend to decide.

Sorry this is a bit long - any thoughts or experiences gratefully received!

There is some evidence that hysteroscopy helps in patients with recurrent implantation failure - it needs to be done in the cycle before the one you have your treatment. No-one seems entirely sure how it works especially if nothing is found to account for implantation failure, but it seems to work!
I've not heard about this trial but it sounds like they are seeing if it helps all patients.
They wouldn't have got ethical approval if it was in any way dodgy but if you are unsure then don't do it.

It cannot hurt if you get the hysteroscopy, and it might help. Given current data it is unlikely to make all the difference if you don't get it, either. As I imagine the doc will have explained, point of the trial is to randomly select who gets what so that they can see if it makes a substantial difference or not and to start to get some info on what characterises those for whom it is a benefit. If the trial shows big benefits they will stop it asap and offer it to everyone.

So if it won't hurt either way and might help if you do get it, I would personally be happy to go ahead. What would help you decide?

I am sorry for your losses. Been there, felt that. I hope it gets better for you.