BRAND NAMES
Celcox (Israel); Celebra (Israel); celebrex (Australia, New-Zealand; Benin, Burkina-Faso, Ethiopia, Gambia, Ghana, Guinea, Ivory-Coast, Kenya, Liberia, Malawi, Mali, Mauritania, Mauritius, Morocco, Niger, Nigeria, Senegal, Seychelles, Sierra-Leone, South-Africa, Sudan, Tanzania, Tunia, Uganda, Zambia, Zimbabwe; Bahrain, Cyprus, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Oman, Qatar, Republic-of-Yemen, Saudi-Arabia, Syria, United-Arab-Emirates, France, Germany, Colombia, Mexico, Hong-Kong, Indonesia, Philippines, Taiwan, Thailand); Celib (India); Coxid (Philippines)
DRUG CLASS
celebrex is a non-steroidal anti-inflammatory agent.
MECHANISM OF ACTION
Celecoxib, a diaryl substituted pyrazole derivative containing a sulfonamide substituent, is a nonsteroidal anti-inflammatory agent (NSAIA).Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and is structurally and pharmacologically related to rofecoxib (Vioxx .. now recalled)
USES
Rheumatoid arthritis, dysmenorrhea, familial adenomatous polyposis, osteoarthritis, and pain.
CONTRAINDICATIONS
Significant - NSAID induced duodenal ulcer, ASA (aspirin) allergy, pregnancy, undiagnosed GI bleeding, GI ulcer, peptic ulcer, duodenal ulcer, gastric ulcer, renal disease, bronchial asthma, dehydration.
Possibly Significant - ACE inhibitors, anticoagulants, luconazole, lithium, loop diuretics, triamterene, amiloride, hepatic disease, congestive heart failure, anemia, fluid retention.
SIDE EFFECTS
Less Frequent - abdominal pain, back pain, diarrhea, dizziness, dyspepsia, flatulence, headache, insomnia, nausea, peripheral edema, pharyngitis, rash, rhinitis, sinusitis, upper respiratory infection, aggravated hypertension, allergic dermatitis, allergic reaction, allergy aggravated, alopecia, anemia, angina pectoris, anorexia, anxiety, increased appetite, arthralgia, arthrosis, asthenia, blurred vision, bone disorder, breast fibroadenosis, breast neoplasm, breast pain, bronchitis, bronchospasm, cataracts, cellulitis, chest pain, conjunctivitis, constipation, coronary artery disorder, cough, cystitis, depression, contact dermatitis, diabetes mellitus, diverticulitis, dry mouth, dysmenorrhea, dysphagia, dyspnea, dysuria, ear abnormality, earache, ecchymosis, generalized edema, eye pain, epitaxis, esophagitis, face edema, fever, accidental fracture, gastritis, gastroenteritis, gastroesophageal reflux, glaucoma, hearing loss, hematuria, hemorrhoids, abnormal hepatic function, Herpes simplex infection, Herpes zoster, hiatal hernia, hot flushes, hypercholesterolemia, hyperglycemia, hypertonia, hypoesthesia, hypokalemia, bacterial infection, fungal infection, soft tissue infection, influenza-like symptoms, laryngitis, leg cramps, melena, menstrual disorder, micturition frequency, migrane, moniliasis, genital moniliasis, myalgia, myocardial infarction, nail disorders, neck stiffness, nervousness, neuralgia, neuropathy, otitis media, pain, palpitation, paresthesia, peripheral pain, photosensitivity reaction, pneumomia, prostatic disorder, pruritus, renal calculus, skin disorder, dry skin, skin nodule, somnolence, stomatitis, increased sweating, synovitis, tachycardia, taste perversion, tendonitis, tenesmus, throbocytosis, tinnitis, tooth disorder, urinary incontinence, urinary tract infection, urticaria, vaginal hemorrhage, vaginitis, vertigo, viral infection, vomiting, weight gain.
SOURCES
www.medscape.com
www.mdconsult.com; Mosby's Drug Consult