Ds has severe asthma that the respiratory consultant is struggling to control. He gets temporary relief from steroids but only whilst on high doses and the benefits are short lived. He currently takes three inhalers, montelukast and theophylline but at clinic today he narrowly avoided being admitted again. He has been sent home with information on methotrexate as the consultant wants to try it next and wants ds to think about it. So any one taken it for asthma with good effects or have any opinions?