DH noticed the fish were looking slightly poorly yesterday and said he saw some white spots on them so he went out and brought some white spot treatment and put it in the tank. I've been away from work and got back this morning, checked the water parameters and they are in desperate need of a water change. They do have white spot and the treatment says it works over four days. If I change the water now the medicine will be diluted, but if I don't change the water they are going to be poisoned. So now I'm stuck as to what to do? Do I wait the four days for medicine to work and hope the water doesn't poison them or change the water and hope they have had enough medicine?