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Conception

MTHFR gene mutation

29 replies

LunaB · 13/07/2017 20:31

I've had a few miscarriages so went to see Dr Shahata at The Miscarriage Clinic who did a full blood panel and discovered (amongst other things) I have the MTHFR gene mutation, which means that I cannot absorb Folic Acid in its synthetic form (the form that's in all the preg vits etc.)...

To remedy this, Dr S prescribed an additional Folic Acid supplement of 5,000mg (in addition to the 400 in my Pregnacare vits) but I'm doubting this is the correct advice - as everything I've read states that it makes no difference how much Folic I pump into myself; my body and any future baby simply won't receive it.

SO, after all this reasesrch I've found that a bioavailable (pure) form of Folic Acid, called l-methlyfolate, could be the best solution as my body could absorb this form of the Folic.

Also, apparently this mutation also causes malabsorption of vitamin B12, so I found a different type of preg vits that in addition to containing the recommended 400mg of the l-methlyfolate version of the Folic Acid also contain a form of methyl-B12 which is supposed to help the body use l-methlyfolate...

Now obviously this issue isn't causing the miscarriages (it's something else), but the fact I can't absorb Folic Acid is worrying as it's so vital to conception and pregnancy.

Anybody else have any knowledge or advice on this issue!?

I'm confused and don't want to go against the doctor who's supposed to be helping me, but I just feel that I'm right!!

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Niknak2018 · 20/05/2018 23:06

Thanks moose23ishungry! (I’ve updated my name from lagare)
Really appreciate your message, it helps!!
Congratulations on your gorgeous bundle of joy too😍

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Niknak2018 · 20/05/2018 23:08

Extremely useful Musskittycat. Thanks so much!!!! And congratulations to you also x

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Niknak2018 · 05/06/2018 12:01

Ladies my scan was a success, I’m in total shock and didn’t think it would happen because of this mutation....what a joy!! Just witnessed the cutest vision and heard the loveliest heartbeat, I couldn’t have imagined a better sight and sound. Thank goodness for these fixes!! So far so good, phew

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Misskittycat16 · 05/06/2018 22:46

Congratulations. That's such lovely news. You hardly dare believe it do you?!
Wishing you a very uneventful and happy pregnancy 😊