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AIBU?

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What do we REALLY think about the weight loss jabs?

787 replies

Newbabynewhouse · 20/09/2026 21:52

I've put this on AIBU rather than weight loss jab because I want a neutral audience rather than people who are all using the jab.
What are peoples thoughts on the jab? I'd love to hear from someone educated in the medical field about whether these are actually safe for people without diabetes.
I'm obese and I have lost a stone so far by dieting although it's taking me a long time! I know if I keep trying hard I can lose what I need to. Lots of people I know have started dropping weight from using the jabs and I am tempted however, can't shake a feeling that there's something not quite right.
What I mean by this is... these jabs have been around for years for diabetic people, so why have they only just been 'released' to people despite obesity effecting the NHS for years?
I know a woman who fainted in work the other day with gallbladder issues, she's on the jab.
Also, I'm going to sound a little conspiracy theorist now, but, isn't it odd these jabs became popular straight after people starting refusing to have more covid jabs..?.. I'd love to hear from people with a bit of background info or medical professionals to tell me whether I'm overthinking or if I'm onto something?

OP posts:
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Stormyrose · 21/09/2026 12:33

This thread has me chuckling, nothing like women losing weight to bring out the green eyed monster in other women, 😂

Zempy · 21/09/2026 12:33

LifeOnEnceladus · 21/09/2026 12:27

The success of the injections does demonstrate that all of those claiming they were obese even though they only ever ate a plate of lettuce were not being honest because all the medication does to help them lose weight is reduce their appetites so that they actually eat sensible portions and, miraculously, the laws of physics which they previously denied applied to their bodies have been proved to work! 🤣

However, I think the fewer morbidly obese people there are, the better. Far less needless suffering from avoidable diseases caused by morbid obesity and the mental health difficulties that also often result from that, and it will much better for the NHS to pay for effective preventative interventions rather than far more expensive treatment for related conditions developed later as a result of ongoing morbid obesity. The NHS should do far more preventative medicine in all areas of health because it has far better patient outcomes and cuts costs significantly.

It seems there can be very unpleasant and significant side effects like with many medications so it would be unwise to take them unless everything else had been tried to control the obesity first so I don’t think it would be appropriate for the NHS to start funding this for anybody over a certain BMI without them having support to try other options first without such risks attached. The risks also need to be thoroughly explained to people and the patient’s medical history and family medical history should be thoroughly reviewed beforehand to assess suitability.

People buying the medication online without proper oversight from a doctor is quite concerning but as it’s legal currently for there to be private prescriptions, that is their choice. I would question whether online prescribing ensures patients do actually understand the risks? I also think though that the NHS should be recording the cost of medical treatment required due to adverse side effects caused by private prescriptions of these drugs and if this becomes significant perhaps allowing private pharmacies to prescribe it should be reviewed/ have stricter criteria imposed: there should be a proper cost/ benefit analysis because there’s still a cost to the taxpayer associated with private prescriptions: the cost of treatment for associated pancreas/ gall bladder/ digestive issues and other side effects and adverse reactions treated via the NHS, and given that the significant risks associated with obesity-related illnesses aren’t present in people who are just a little overweight in these cases there is not the associated cost saving to the NHS/ taxpayer to outweigh the cost of treating the side effects in the unlucky ones who are just a bit overweight and obtain private prescriptions outside the NHS criteria then have an adverse reaction. It may be good value for money, or not, but data needs to be collected by weight, BMI, dose, type of side effect, cost of treatment so that rational and evidence-based criteria for the permissibility of private prescribing can be issued.

It’s interesting and positive that research is uncovering health benefits from these drugs in addition to them being appetite suppressants however, there are clearly significant risks and we need to ensure these are being accurately recorded and managed and weighed against the benefits (excuse the pun!). There’s certainly a risk that some people may be taking them as a lifestyle drug rather than due to medical need when other interventions would be far less dangerous and equally effective if diets etc were actually followed because ultimately that’s exactly what the drugs get people to do, but with these added risks. Overall though, they seem to be helping a lot of people be healthier who couldn’t manage to eating sensible portions/ healthy food of their own accord and it seems to have been transformative for many. It’s annoying that these topics often descend into polarised extreme views often ignoring the facts that don’t fit a poster’s personal viewpoint or narrative so it’s good to see (some!) posters here having a balanced discussion.

You fail to appreciate that many of us were gaining weight on fairly low calorie intake. My metabolism has been thoroughly assessed by my consultant endocrinologist. He confirmed that I would gain if I exceeded around 1350 calories a day.

I am sure you can see that trying to get substantially under that level, in order to lose weight is incredibly difficult for most people. The hormones in the medication allow me to keep my intake to a level that my metabolism can cope with. I have maintained for a year now.

It just isn’t as simple as many people think it is.

SilenceInside · 21/09/2026 12:36

@mulberrymilk I think we are all very well aware of the risks of gallbladder issues. It's mentioned in all the literature, in the patient info leaflet that comes with the medication, on the online consult forms, in the information on pharmacy websites, in their email communications, via their apps and endlessly mentioned on discussion threads about WLI on here. You'd have to be particularly inobservant to miss all of that.

I have been on Mounjaro for over 2 years now, for weight loss. I imagine my gallbladder troubles or gastroparesis are just around the corner, given what you say here. I wait with anticipation! In the meantime, I have lost 11 stone.

Teainapinkcup · 21/09/2026 12:36

Newbabynewhouse · 20/09/2026 21:52

I've put this on AIBU rather than weight loss jab because I want a neutral audience rather than people who are all using the jab.
What are peoples thoughts on the jab? I'd love to hear from someone educated in the medical field about whether these are actually safe for people without diabetes.
I'm obese and I have lost a stone so far by dieting although it's taking me a long time! I know if I keep trying hard I can lose what I need to. Lots of people I know have started dropping weight from using the jabs and I am tempted however, can't shake a feeling that there's something not quite right.
What I mean by this is... these jabs have been around for years for diabetic people, so why have they only just been 'released' to people despite obesity effecting the NHS for years?
I know a woman who fainted in work the other day with gallbladder issues, she's on the jab.
Also, I'm going to sound a little conspiracy theorist now, but, isn't it odd these jabs became popular straight after people starting refusing to have more covid jabs..?.. I'd love to hear from people with a bit of background info or medical professionals to tell me whether I'm overthinking or if I'm onto something?

Dieting is the ONLY SAFE HEALTHY WAY to lose the weight, its a mind game. Slimming world does work if you do not obsess about massive portions of carb and fitting chemical filled crap into the swips. Also calorie counting works too. Eating less shit and more actual wholefoods in decent normal portion sizes is important.

Teainapinkcup · 21/09/2026 12:38

Stormyrose · 21/09/2026 12:33

This thread has me chuckling, nothing like women losing weight to bring out the green eyed monster in other women, 😂

none of us that hate the thought of these WLI are jealous of you lot... trust me.

Stormyrose · 21/09/2026 12:40

Teainapinkcup · 21/09/2026 12:38

none of us that hate the thought of these WLI are jealous of you lot... trust me.

😂

Teainapinkcup · 21/09/2026 12:41

Newbabynewhouse · 20/09/2026 21:52

I've put this on AIBU rather than weight loss jab because I want a neutral audience rather than people who are all using the jab.
What are peoples thoughts on the jab? I'd love to hear from someone educated in the medical field about whether these are actually safe for people without diabetes.
I'm obese and I have lost a stone so far by dieting although it's taking me a long time! I know if I keep trying hard I can lose what I need to. Lots of people I know have started dropping weight from using the jabs and I am tempted however, can't shake a feeling that there's something not quite right.
What I mean by this is... these jabs have been around for years for diabetic people, so why have they only just been 'released' to people despite obesity effecting the NHS for years?
I know a woman who fainted in work the other day with gallbladder issues, she's on the jab.
Also, I'm going to sound a little conspiracy theorist now, but, isn't it odd these jabs became popular straight after people starting refusing to have more covid jabs..?.. I'd love to hear from people with a bit of background info or medical professionals to tell me whether I'm overthinking or if I'm onto something?

dh work mates mum died from using the WLI she got the pancreatitis. He said why didn't his mum just do slimming world. Sad, since he is fairly young and lost his dad also, so now no parent. People are selfish, simple as that. Eat less... Eat wholefoods... Get rid of refined sugar, or at least eat it at a minimum as that can drive hunger.

Teainapinkcup · 21/09/2026 12:41

Stormyrose · 21/09/2026 12:40

😂

Honestly. Lol I have lost on calorie counting. Does not cost a penny.

Chickpeacurrywithrice · 21/09/2026 12:44

OonaStubbs · 20/09/2026 23:32

I don't like them at all.

It's not fair on people who have lost weight through use of exercise and willpower. Some people will still be eschewing the use of these drugs and doing it the old fashioned way, yet people will think they are cheating by shooting up drugs. To me it is no different to sports people taking performance enhancing drugs.

Well you need to educate yourself then!

”Shooting up drugs” 😀😀😀

And other people will think you’ve been using them if you lose weight? Are you really that sensitive you’d be bothered by that?

Chickpeacurrywithrice · 21/09/2026 12:45

Teainapinkcup · 21/09/2026 12:38

none of us that hate the thought of these WLI are jealous of you lot... trust me.

🤔

mulberrymilk · 21/09/2026 12:47

SilenceInside · 21/09/2026 12:36

@mulberrymilk I think we are all very well aware of the risks of gallbladder issues. It's mentioned in all the literature, in the patient info leaflet that comes with the medication, on the online consult forms, in the information on pharmacy websites, in their email communications, via their apps and endlessly mentioned on discussion threads about WLI on here. You'd have to be particularly inobservant to miss all of that.

I have been on Mounjaro for over 2 years now, for weight loss. I imagine my gallbladder troubles or gastroparesis are just around the corner, given what you say here. I wait with anticipation! In the meantime, I have lost 11 stone.

I was responding after a slew of posters declared that it was nothing to do with the WLI themselves, that it was just a side-effect of rapid weightloss.

It is clearly not just that, according to the meta-analysis.

borborygmus1 · 21/09/2026 12:56

Whatalunatic · 21/09/2026 10:24

Most people don't eat enough protein? How could you possibly know?

I was more than 20 stone. What do you consider would have happened to me if I had continued that way? What was the alternative, given that I'm in my 50s and tried every diet going for many years? Any method of weight loss is going to cause muscle loss, you know that right? You assume, like so many on here, that being obese is the same as being utterly stupid. You assume that there's no personal accountability, that I'm somehow unable to research what to do and how to help myself. You assume I'm unable to do whatever is necessary to maintain my overall health because....I was obese.

WLIs have literally saved my life. I will hopefully now be around for grandchildren. The loss of weight means I can now exercise - there are no excuses anymore. I can move. I don't hurt. Wearing a dress today that is 6 sizes smaller than the one I was wearing this time last year (and it's the same dress 'cos I loved it, found this one in a smaller size on Vinted). That is possibly the most motivating thing ever!

I was not and am not stupid. I am an educated professional. There were many reasons for my weight including genetics, the way I was taught to handle food from childhood, some abuse, low self esteem and other stuff. But mainly....there was a point of no return and I passed it. It became impossible to go back. I'm there now, thankfully right on time and thankfully I have been able to afford it. I know many aren't so lucky.

What part of my answer called you stupid?

What on earth in my post made you feel as if I was telling YOU, as a complete stranger who I have zero knowledge of, what to do?

OP asked what we think, and I answered for myself opening with the words, 'I PERSONALLY' Also, your post is simply incorrect. It is entirely possible to gain muscle while losing weight. I work with colleagues with PhDs in osteology and muscular health, so I do have awareness on the effects of not eating enough protein with weight loss medications. Unfortunately due to the appetite suppression side effects, it is very common.

I’m glad you’ve weighed up the risks and benefits for yourself and found something that works for you. Good for you. But as stated, I PERSONALLY (defined as: I, myself) would not use them. My priority is avoiding sarcopenia down the line; I worry about my future falls risk and losing my independence as I age.

You make your choices, I’ll make mine. Stop projecting.

Stormyrose · 21/09/2026 13:14

Teainapinkcup · 21/09/2026 12:41

dh work mates mum died from using the WLI she got the pancreatitis. He said why didn't his mum just do slimming world. Sad, since he is fairly young and lost his dad also, so now no parent. People are selfish, simple as that. Eat less... Eat wholefoods... Get rid of refined sugar, or at least eat it at a minimum as that can drive hunger.

studies now show there is no increase in pancreatitis due to weight loss meds, and in fact the opposite it protects your pancreas and reduces the cases of pancreatic cancer too.

im sorry she died, but the pancreatitis wasn’t due to the meds, factually not one person has died globally due to correct usage of the legitimate medication. I’d ask for more info,

LifeOnEnceladus · 21/09/2026 13:14

Zempy · 21/09/2026 12:33

You fail to appreciate that many of us were gaining weight on fairly low calorie intake. My metabolism has been thoroughly assessed by my consultant endocrinologist. He confirmed that I would gain if I exceeded around 1350 calories a day.

I am sure you can see that trying to get substantially under that level, in order to lose weight is incredibly difficult for most people. The hormones in the medication allow me to keep my intake to a level that my metabolism can cope with. I have maintained for a year now.

It just isn’t as simple as many people think it is.

I don’t think it is particularly difficult to prepare meals at 1350 calories per day if someone plans meals sensibly and eats regular portion sizes. It’s certainly perfectly possible because that’s precisely what people do as a result of taking these drugs or when they diet naturally! Normal calorie intake for a woman should be 1600-2000 calories and only at the higher end of that if you are quite tall/ young/ very active (which most obese people are not). For weight loss 1200 to 1500 is quite normal so I don’t think 1350 is extreme? It just means making slightly healthier choices for most meals.

If someone has diabetes or pre-diabetes or insulin resistance etc causing metabolic issues then of course the balance of risks and benefits will be different (although often things like insulin resistance are of course caused in the first place by poor diet/ over eating/ lack of exercise).

My comment was not about people who have other separate health conditions which the drug has been shown to improve, but people who are taking these drugs purely for weight loss.

Stormyrose · 21/09/2026 13:15

borborygmus1 · 21/09/2026 12:56

What part of my answer called you stupid?

What on earth in my post made you feel as if I was telling YOU, as a complete stranger who I have zero knowledge of, what to do?

OP asked what we think, and I answered for myself opening with the words, 'I PERSONALLY' Also, your post is simply incorrect. It is entirely possible to gain muscle while losing weight. I work with colleagues with PhDs in osteology and muscular health, so I do have awareness on the effects of not eating enough protein with weight loss medications. Unfortunately due to the appetite suppression side effects, it is very common.

I’m glad you’ve weighed up the risks and benefits for yourself and found something that works for you. Good for you. But as stated, I PERSONALLY (defined as: I, myself) would not use them. My priority is avoiding sarcopenia down the line; I worry about my future falls risk and losing my independence as I age.

You make your choices, I’ll make mine. Stop projecting.

Edited

Gosh people get so so angry these drugs are available, effective and safe, it’s really sad,

peppy23 · 21/09/2026 13:16

Teainapinkcup · 21/09/2026 12:38

none of us that hate the thought of these WLI are jealous of you lot... trust me.

Could have fooled me 😂

mulberrymilk · 21/09/2026 13:17

Stormyrose · 21/09/2026 13:14

studies now show there is no increase in pancreatitis due to weight loss meds, and in fact the opposite it protects your pancreas and reduces the cases of pancreatic cancer too.

im sorry she died, but the pancreatitis wasn’t due to the meds, factually not one person has died globally due to correct usage of the legitimate medication. I’d ask for more info,

No, they showed there is a slightly increased risk, but that the overall risk is low.

From January this year

A new safety warning to doctors and patients around a rare but potentially fatal side effect of glucagon-like peptide-1 (GLP-1) receptor agonists has been issued by UK regulators.

Sold under brands like Ozempic, Wegovy, and Mounjaro, GLP-1 injections are for weight loss and to treat type 2 diabetes.

But their use has been linked to a rare risk of developing pancreatitis, a dangerous inflammation of the pancreas that can prove fatal in extreme cases.

GLP-1 drugs: New warning after rise in reported deaths from pancreatitis | The BMJ

LifeOnEnceladus · 21/09/2026 13:17

mulberrymilk · 21/09/2026 12:31

It's not just the slowing of the gallbladder emptying. From the quoted para:

"Furthermore, fasting keeps the gallbladder inactive, leading to a buildup of thick bile, which eventually leads to the formation of gallstones."

So, although several posters claimed it was nothing to to with the WLI themselves, apparently it is. Care of:

  • Reduced gallbladder motility: GLP-1 slows gallbladder emptying, causing bile to remain longer in the organ, which promotes stone formation
  • Rapid weight loss: Accelerated fat loss can alter bile composition, increasing the likelihood of gallstone formation
  • Changes in bile metabolism: GLP-1 RAs may influence bile acid secretion and flow, further contributing to gallbladder disease risk

Meta-analyses of 76 randomized clinical trials involving over 100,000 participants show that GLP-1 RAs increase the risk of gallbladder or biliary diseases by approximately 37% compared to controls (RR 1.37, 95% CI 1.23–1.52) (He et al., 2022) Specific conditions affected include gallstones (cholelithiasis, RR 1.27), gallbladder inflammation (cholecystitis, RR 1.36), and overall biliary disease. The risk is dose-dependent, duration-dependent, and higher in weight loss trials than in diabetes trials, with weight loss studies showing more than double the risk (RR 2.29)

That's a suprisingly high increase in risk. I'm not sure how accurate that is. But it is certainly something to bear in mind if you're on WLI and having symptoms.

Wow, that is concerning given it’s been presented as a “rare” side effect. That’s not a small increase in risk at all especially for something so serious.

LifeOnEnceladus · 21/09/2026 13:19

Stormyrose · 21/09/2026 13:15

Gosh people get so so angry these drugs are available, effective and safe, it’s really sad,

Why do you think people are angry about it? 🧐

peppy23 · 21/09/2026 13:19

Teainapinkcup · 21/09/2026 12:41

dh work mates mum died from using the WLI she got the pancreatitis. He said why didn't his mum just do slimming world. Sad, since he is fairly young and lost his dad also, so now no parent. People are selfish, simple as that. Eat less... Eat wholefoods... Get rid of refined sugar, or at least eat it at a minimum as that can drive hunger.

Got the pancreatitis?

it is just pancreatitis there’s no the.

You sound like a right dick tbh.

maximc · 21/09/2026 13:23

I lost loads of weight on Mounjaro, developed gall stones, & had my gallbladder removed in an operation that was much easier because of the weight loss. There is a tiny possibility some kind of serious long term effects we don't know about yet will happen because of GLP 1s, but I was happy to risk it. I was never able to lose weight naturally & keep it off because I have a ridiculously large appetite, which I may have been born with, as my parents remember me being obsessed with food even as a tiny child.

Fatasawalrus · 21/09/2026 13:23

ThreadGuardDog · 21/09/2026 12:13

Is there any need to be so rude ? No I don’t think you’re stupid - I was simply recounting my experience with my DH. He is on Mounjaro for type 2 diabetes and says that if he really wants to override the appetite suppressant effect it’s quite easy to do so - for example on the rare occasions we go out to eat, or have a takeaway. The main effect of the drug as far as he’s concerned is that it stops the ‘food noise’ so it’s easier to control intake. He still needs to watch his fat intake as there are unpleasant side effects to that, and there still has to be a calorie deficit, which I acknowledged is easier to achieve with WLI’s.

Edited

Sorry for the tone of my message but what you wrote just really got to me.

“There still has to be a calorie deficit - OK easier to achieve with Mounjaro, but you can’t just eat what you like and expect the weight to just fall off. The time on WLI’s is best used to change eating habits and learn what works best for you.”

Saying to someone that it’s not a case that you can eat what you like and the weight will fall off is absolutely treating thst person as ignorant at the least.

It really touched a nerve. I AM maintaining my weight loss but I have accepted that I cannot lose more AND maintain it. I’ve worked out my TDEE and monitor what I eat and weigh regularly so I have educated myself on what my body does. There is nothing wrong with what I eat. Actually ironically if I bought and ate crap I might be able to afford WLI. I prioritise good food. It would absolutely be possible for me to lose those final two stones if I could quieten the food noise and feel satiated at a lower calorie level.

I’m pleased things are going well for your husband.

peppy23 · 21/09/2026 13:24

LifeOnEnceladus · 21/09/2026 13:17

Wow, that is concerning given it’s been presented as a “rare” side effect. That’s not a small increase in risk at all especially for something so serious.

A biologically plausible explanation for many reported cases is gallstone-mediated pancreatitis secondary to rapid weight loss, rather than a drug-specific inflammatory mechanism. Rapid weight loss of any cause, including very low calorie diets and bariatric surgery, is a recognised risk factor for gallstone formation through bile supersaturation, impaired gallbladder emptying, and bile stasis. Gallstones remain the most common cause of acute pancreatitis in clinical practice.¹ ²
Randomised trial evidence shows GLP-1 receptor agonists are associated with an increased risk of gallbladder and biliary disease, particularly at higher doses, longer duration, and when used for weight loss.³ This association provides a coherent mechanistic pathway linking treatment-related weight loss to gallstone formation and subsequent pancreatitis, without invoking a direct pancreatic effect.
The apparent rise in pancreatitis reports should also be interpreted in the context of unprecedented exposure and heightened awareness. With more than 25 million packs dispensed in the UK and an estimated 1.6 million users, rare adverse events will inevitably become more visible. Spontaneous reporting systems are essential for signal detection but cannot establish incidence or causality.

this is interesting of course given the monumental uptake of the jabs you will hear more stories.

but people are failing to acknowledge that you are already at an increased risk anyway if you are fat.

Fatasawalrus · 21/09/2026 13:25

Stormyrose · 21/09/2026 13:15

Gosh people get so so angry these drugs are available, effective and safe, it’s really sad,

What’s really sad is that they aren’t available to everyone who might benefit.

Whatalunatic · 21/09/2026 13:27

MummyJ36 · 21/09/2026 11:18

Yes that’s true, I think we’re saying them same thing more than you realise 😂 WLJ are really just another form of crash dieting (that happens to be more socially acceptable in my personal opinion), so if you have little need to lose weight then I don’t personally think the benefits outweigh the risks. If you are seriously obese then the weight loss (no matter what form it comes in) may outweigh the risks but only alongside other help to understand why you reached that point in the first place.

A pound a week - which is my experience (other than the very beginning) is hardly can hardly be considered a crash diet, can it? If I lost a pound a week by eating less and going to the gym, you'd be all over me. But I lose a pound a week with an injection, eating less and going to the gym I'm 'cheating' and somehow morally degenerate?! How does that work then?

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