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Help! Ive had a glass of wine and need to take nytol

64 replies

Sc0tlandbye · 04/09/2026 20:26

I had a large (okay, very large) glass of wine.
Am I okay to take Nytol in 3 or 4 hours? Ice been going through a terrible bout of insomnia and really need to be operational tomorrow:(

OP posts:
MissCooCooMcgoo · 04/09/2026 21:27

Mixing anything that makes you drowsy with alcohol is a mistake.

Zopiclone for example mixed with alcohol can cause you to stop breathing in your sleep.

From the web: Dangers of Combining Nytol and Alcohol

  • Severe Drowsiness: Both substances make you sleepy. Together, they cause extreme sedation that makes it hard to wake up or stay alert.
  • Slowed Breathing: Both slow down brain function. Combining them can lead to shallow or troubled breathing, which is life-threatening.
  • Poor Coordination: You face a much higher risk of dizziness, confusion, and accidental falls.
Dryshampoofordays · 04/09/2026 21:27

I think mixing it will be fine (as a one off, probably not a good idea to make it a regular thing) unless you’re so worried about overdose that the anxiety wakes you in a panic! If sleep is a problem you really need to stop drinking for a while op, just one alcoholic drink can wreck your sleep

NeverDropYourMooncup · 04/09/2026 21:30

CheeseWisely · 04/09/2026 21:07

I’m pretty sure if one nytol mixed with a moderate amount of alcohol could kill you it would be in bold (or at least italics) somewhere in the leaflet.

I'm pretty sure that the the bit saying Do not drink alcohol on the leaflet and printed on the box is a bit of a clue.

NeverDropYourMooncup · 04/09/2026 21:30

CheeseWisely · 04/09/2026 21:07

I’m pretty sure if one nytol mixed with a moderate amount of alcohol could kill you it would be in bold (or at least italics) somewhere in the leaflet.

dupe

Ineffable23 · 04/09/2026 21:32

Frumpitydoo · 04/09/2026 20:59

Promethazine is available over the counter and is what they use in hospitals for insomniac patients now Zopiclone et al are being phased out. You need a 40-50mg dose for sleep. You are welcome!

I find promethazine really useful for sleep - just makes me drowsy enough that I drop off again if I wake up. But I definitely don't need 50 mg! I find 12.5mg is plenty, and if I take a full 25mg then I struggle to get going the next day. I usually buy mine from an online pharmacy - I tend to do a fairly chunky order once or twice a year with this, own brand Gaviscon, thrush medication, a giant batch of ibuprofen , hydrocortisone cream, and anything else that irritates me buying from boots due to the price!

fashionqueen0123 · 04/09/2026 21:32

Frumpitydoo · 04/09/2026 20:59

Promethazine is available over the counter and is what they use in hospitals for insomniac patients now Zopiclone et al are being phased out. You need a 40-50mg dose for sleep. You are welcome!

I took that for pregnancy sickness. I woke up at 2am needing a wee and felt like a zombie. I remember trying not to bang into the door!
A family friend took it years back when it was used for hay fever before modern non drowsy anti histamines . She went to see a show and woke up at the end 🤣
So can confirm it makes you sleep!

Middlemarch123 · 04/09/2026 21:35

Frumpitydoo · 04/09/2026 20:59

Promethazine is available over the counter and is what they use in hospitals for insomniac patients now Zopiclone et al are being phased out. You need a 40-50mg dose for sleep. You are welcome!

Nytol doesn’t contain Promethazine.
Promethazine is available over the counter in UK in Night Nurse and Sominax.
My DS is prescribed it.

PrettyLittleRose · 04/09/2026 21:37

Just looked it up. No you should not take the Nytol after wine @Sc0tlandbye SORRY. I shouldn't have given that frivolous advice without knowing about it properly... Best to give the Nytol a swerve tonight. The big glass of wine should help you sleep. Smile

Here's what I got when I googled it. I have asked for my other post to be removed. xx

No, you should not drink a glass of wine before taking NYTOL.

Why Mixing is Unsafe

  • Increased Drowsiness: Both alcohol and Nytol slow down your brain and central nervous system. Mixing them makes you much more sleepy and dizzy than normal.
  • Slow Breathing: Combining alcohol and sleep aids can cause dangerous breathing problems, making your breath very slow and shallow.
  • Risk of Falls: The heavy sedation can cause confusion, poor balance, and a high risk of falling, especially if you get up during the night.
  • Overwhelming the Liver: Your liver processes both substances. Taking them together puts extra stress on your body.
likelysuspect · 04/09/2026 21:38

Magnesium if the issue is waking up early hours.

likelysuspect · 04/09/2026 21:39

Middlemarch123 · 04/09/2026 21:35

Nytol doesn’t contain Promethazine.
Promethazine is available over the counter in UK in Night Nurse and Sominax.
My DS is prescribed it.

The poster didnt say Nytol containes promethazine.

Fizbosshoes · 04/09/2026 21:46

likelysuspect · 04/09/2026 21:38

Magnesium if the issue is waking up early hours.

Magnesium is nowhere near as reliable for that (for me) as Nytol

Strawberrydelight78 · 04/09/2026 21:49

I’m on Mirtazapine also take Kalms one a night as well or I don’t sleep. Sometimes after alcohol never wait 4 hours it’s usually about an hour always been fine. So I’m sure you taking Nytol will be ok.

Askandyforcompo · 04/09/2026 22:11

I've taken Nytol with wine lots of times. I was fine but it never had any negatives for me, never felt groggy etc, even without wine.

Sc0tlandbye · 04/09/2026 22:30

Askandyforcompo · 04/09/2026 22:11

I've taken Nytol with wine lots of times. I was fine but it never had any negatives for me, never felt groggy etc, even without wine.

Thats reassuring! Ive never had priblems with nytol either, always feel great upon waking

OP posts:
DeanGaffneysCumFace · 04/09/2026 22:58

Strawberrydelight78 · 04/09/2026 21:49

I’m on Mirtazapine also take Kalms one a night as well or I don’t sleep. Sometimes after alcohol never wait 4 hours it’s usually about an hour always been fine. So I’m sure you taking Nytol will be ok.

I had to come off mirtazapine because it made me sleep 18 hours a day, it was horrible. When they diagnosed me with bipolar I was put on Quetiapine and I had to come off that within 7 days as the restless legs nearly ended me.
I can't cope with the 'pines meds.

As for the nytol and 1 wine, you should be fine but it's up to you to decide

putitonthewrongway · 04/09/2026 23:02

Frumpitydoo · 04/09/2026 20:59

Promethazine is available over the counter and is what they use in hospitals for insomniac patients now Zopiclone et al are being phased out. You need a 40-50mg dose for sleep. You are welcome!

That’s what they say but crikey they knock me out and I’d never get up the next day! 25mg is enough for me especially after a glass of wine!

Maddy70 · 04/09/2026 23:04

Yes of course you are ok

Radioheads · 04/09/2026 23:15

I have and it has never caused me a problem. The 10 gram amount.

Shellityhorn · 04/09/2026 23:32

Sc0tlandbye · 04/09/2026 22:30

Thats reassuring! Ive never had priblems with nytol either, always feel great upon waking

Nor me, and I’ve certainly mixed it either alcohol in the past. Though, curiously, Nytol seems to act very differently on different people. I felt sleepy about 20 minutes after taking it. DH needs an hour to an hour and a half for it to hit. He says he feels it in the morning. I never did.

Id say avoiding longterm use is probably more important, OP.

Fizbosshoes · 04/09/2026 23:46

I occassionally take the boots own version. The warning not to take with alcohol has worked with me, so i never have but I do sometimes feel zombie-ish in the morning. Im pretty small for an adult (v short and below average weight so I dont know if it has a bigger impact)

HappiestSleeping · 05/09/2026 00:20

To all my fellow insomniacs, we should look on the bright side. Only four more sleeps until Christmas. 🤦‍♂️

Sc0tlandbye · 05/09/2026 04:27

Ffs took the nytol but awake at 4 😭

OP posts:
JacquesHarlow · 05/09/2026 05:41

Sc0tlandbye · 05/09/2026 04:27

Ffs took the nytol but awake at 4 😭

what aspect about your life @Sc0tlandbye are you willing to take control of?

You said you “need” to take a Nytol. Did you “need” to have a glass of wine last night also, if it turns out you could have anticipated you would “need” Nytol later on?

Or worse, do you accept that the alcohol itself could be keeping you awake?

Do you suffer from anxiety, do you have weight or health issues which could be exacerbating staying awake?

I feel for you with insomnia (ignore the time I’m posting, I’m about to go to the gym, this is normal for me) but I also think that without confronting the other root causes of things, or saying to yourself “if Nytol is the only things that works for me, I’ll forgo alcohol for a bit”, then you’re just chasing round in a circle

SpanThatWorld · 05/09/2026 07:26

Sc0tlandbye · 04/09/2026 21:05

Interesting! So you can just walk into Boots and request this?

It's Phenergan. One of the old school "knock you out with a mallet" antihistamines.

SwanUpmanship · 05/09/2026 07:46

SpanThatWorld · 05/09/2026 07:26

It's Phenergan. One of the old school "knock you out with a mallet" antihistamines.

Yes, I can vouch for this😆

If you take it with alcohol, though, you are totally out for the count within 15 mins and falling asleep all the next day too - really would not recommend it after wine.