eeling desperate - anyone have any experience of estrogel/utrogestan regime for PMDD? Have had underlying panic disorder my entire life which I was happily on sertraline for. Had PND with first son aged 30 but, until this point and after was on depo provera (injection of pill that stops ovluation/periods) from 18 to 35 apart from when pregnant or trying for a baby. So had never had a monthly cycle until 3 years ago. When I started to have a monthly cycle i noticed that from day 14 (ovulation) for 2 weeks, until my period started, i felt hugely anxious, depressed and panicky with terrible dark moods and thoughts. I have been put on a regime of 2 pumps of estrogel (now up to 4) and utrogestan (which I started with 2 capsules 12 days per month but am now on 1 capsule, 7 days a month because I had been advised to take it to coincide with the last 12 days of my cycle and it made me pretty much suicidal, exaggerating all the, already horrendous, bits of the last 2 weeks of the month). I havent noticed any improvement on this regime at all (its been 6 months now) and I am keen to hear from anyone who has been on more than 4 pumps of estrogel and found that it did, eventually, improve things or anyone who went down a similar path as this one and found it didnt work for them (and what did). I really need some hope here! I really appreciate you reading this, rather long, read and for your input.