Has anyone found Mounjaro affects mood while cutting down alcohol?

[FlowerPow8r83]

Afternoon guys,
Thought I'd pop on and see if there's anyone else feeling the same.

So I'm 43yrs old, recently diagnosed with inactive ADHD which explains A LOT! I'm currently awaiting medication (If I decide to go down that route at all).

I've been drinking pretty heavy for the past 10yrs (1- 1.5 bottles of wine a night, more at the weekend) and have never really batted an eyelid about it as everyone I know seems to do the same thing. All our friends work in hospitality so there's always a pub to visit or an occasion to celebrate.

I never get hangovers, can drink a fair bit without getting drunk and my tolerance is getting higher. Alcoholism has affected several people in my family so I'm aware it's something I need to be careful of which is why I'm making changes.

I now know why I drink and it's because it silences my 100mph adhd brain. 2 drinks in and I start to fee 'normal'. It literally silences my brain and I feel instantly relaxed. I then spend the next few hours chasing that fix.

I have tried to reduce my drinking before but admit i have found it difficult to break the habit. Here's where GLP1 comes into it. Due to drinking so much daily, I have at least 16lbs to shift so decided to get Mounjaro.

I'm on day 3, cravings for a drink have completely gone but so has any other form of dompamine. Tbh, I feel pretty flat and meh. First night I took the jab and some vitamins and slept a solid 8.5hrs but woke up exhausted. Last night, another 8hrs but woke up feeling tired and really flat. I'm eating little and often, sticking with protein first and drinking all my water etc. I've had no side effects yet like sickness, nausea etc.

I'm just not sure if the mood change is the jab, the withdrawal or both. My aim to lose some weight, stay off the drink for a bit and gradually introduce it on occasions instead of a daily habit.

Not sure if anyone has had similar feelings but thank you for reading.

I can't speak to the mounjaro, but Day 3 off a substantial intake of alcohol is the hard yards! You will definitely be in withdrawal from that, possibly even the worst day at this stage, and the answer is to be super-kind and gentle with yourself... 🤗

Make sure you eat enough, keep lightly busy or entertained, get a gentle walk in the fresh air, lots of water, vitamins (especially the B complex) and as much sleep as you can manage. Treat yourself as if you're recovering from an illness. You will feel better, but it'll take a little time. It will be SOOO worth it, and will make your choices about medication so much easier when you're not throwing alcohol into the mix.

You can't decide the future on how you feel today. Give it some time, a fair go.

And well done for taking the decision to rethink the booze - you will have so much support from others who've done the same, even if your hospitality friends don't get it!

Cheering you on! 👏

Thank you so much for your kind words ❤️

I'm currently taking iron, high strength vit B complex, high strength thiamine, vit d and a hair supplement.

Work has been a godsend tbh cos I'm keeping busy and usually I'll be looking forward to passing M&S on the way home to pick up my wine and snacks but it hasn't even entered my mind. I got bored of romanticising alcohol in the end.

Just been reading about 'sobriety fatigue'. Didn't even know that was a thing tbh. Can relate to a lot of it.

I got sober a few years before starting MJ and I remember well how awful I dorky for the first week while. It definitely got easier though but it was basically what you describe. I’m also diagnosed with ADHD so can relate to the alcohol switching off the brain to an extent. I didn’t find any negatives of being on MJ, in fact over time it has made my mood far better, although o realise a lot of that is confidence relating to losing a significant amount of weight.

Well done on both sobriety and your weight loss. Bet you feel amazing!

I'm the same, used to be a heavy drinker, functional alcoholic - then found out it was tied to my ADHD.
I'm medicated now.
Occasionally I'll fall back into old habits and notice a significant difference in my mood.
You need to find another source of dopamine I'm afraid.
I find I need to go outside to keep myself steady. Bring in nature with all the sensory input works wonders for me. Outdoor swimming/dipping is another. Lifting heavy weights, rugby, learning new things, languages/history etc helps too. I also do wood carving.
Basically anything that keeps my brain and body active to keep the ADHD at bay.

Good luck, the booze is great at the time, but our brains are particularly sensitive to the bad side of it. Good work for making changes.

It's been being trialed on alcohol issues.

https://www.recoveryanswers.org/research-post/glp-1-medications-next-big-thing-alcohol-use-disorder-treatment/

Saffron is useful for a little mood boost and adhd help pre your meds. Theanine is good for bedtime brain switch off and chill. Again well done!!!!!!! What an achievement. Keep going x

It will be alcohol withdrawal rather than the jab. That’s a significant amount of alcohol.

Congrats on making healthier decisions. I did the same. I’ve lost 5 stone on the jab. Rarely drink and don’t want too anymore.

As someone who doesn’t drink much (once every month or so and never more than a few) I can attest to the meh effect of the Mounjaro. It left me feeling really quite flat. I enjoyed stuff once I was doing it but mustering up the effort to go and do or engage was hard work. So could be the lack of alcohol, could be the Mounjaro.

This will be alcohol withdrawal. Alcohol is a depressant. Your body is going to go through some hard feelings like this as it adjusts.

Mounjaro impacts the pleasure centre in your brain as part of its impact. Food doesn’t give you the high, nor alcohol, nor smoking or gambling, both of which are using mounjaro in trials.

It’s medication that is risky for your mental health if good health relies on dopamine rewards. There is quite a lot of research around this because of that loss of dopamine hit and the flatness as a result. You do get used to the lack of reward - for me it was from food more than booze - but you have to find alternates to get that hit. My choice is exercise and sex. Whatever works.

this is a good article, but there is plenty around: www.theguardian.com/science/2026/apr/06/is-retatrutide-experimental-weight-loss-drug-making-people-fall-out-of-love